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dc.contributor.authorLapinlampi N
dc.contributor.authorMelin E
dc.contributor.authorAronica E
dc.contributor.authorBankstahl JP
dc.contributor.authorBecker A
dc.contributor.authorBernard C
dc.contributor.authorGorter JA
dc.contributor.authorGröhn O
dc.contributor.authorLipsanen A
dc.contributor.authorLukasiuk K
dc.contributor.authorLöscher W
dc.contributor.authorPaananen J
dc.contributor.authorRavizza T
dc.contributor.authorRoncon P
dc.contributor.authorSimonato M
dc.contributor.authorVezzani A
dc.contributor.authorKokaia M
dc.contributor.authorPitkänen A
dc.date.accessioned2017-03-17T12:00:27Z
dc.date.available2017-03-17T12:00:27Z
dc.date.issued2016
dc.identifier10.1016/j.eplepsyres.2016.11.010
dc.identifier.issn0920-1211
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/705
dc.descriptionArticle
dc.description.abstractLack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data collection and analysis, and has been used for a long time in clinical studies testing anti-seizure drugs. EPITARGET is a European Union FP7-funded research consortium composed of 18 partners from 9 countries. Its main research objective is to identify biomarkers and develop treatments for epileptogenesis. As the first step of harmonization of procedures between laboratories, EPITARGET established working groups for designing project-tailored common data elements (CDEs) and case report forms (CRFs) to be used in data collection and analysis. Eight major modules of CRFs were developed, presenting >1000 data points for each animal. EPITARGET presents the first single-project effort for harmonization of preclinical data collection and analysis in epilepsy research. EPITARGET is also anticipating the future challenges and requirements in a larger-scale preclinical harmonization of epilepsy studies, including training, data management expertise, cost, location, data safety and continuity of data repositories during and after funding period, and incentives motivating for the use of CDEs.
dc.language.isoEN
dc.publisherElsevier BV
dc.relationinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/602102///EPITARGET
dc.relation.ispartofseriesEPILEPSY RESEARCH
dc.relation.urihttp://dx.doi.org/10.1016/j.eplepsyres.2016.11.010
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCommon data element
dc.subjectDatabase
dc.subjectData management
dc.subjectEpileptogenesis
dc.subjectEpilepsy
dc.titleCommon data elements and data management: Remedy to cure underpowered preclinical studies
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionfinal draft
dc.contributor.departmentA.I. Virtanen -instituutti
dc.contributor.departmentA.I. Virtanen Institute / Neurobiology
uef.solecris.id45005405
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Elsevier B.V.
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/602102///EPITARGET
uef.citationinfo.pages87-90
dc.relation.doi10.1016/j.eplepsyres.2016.11.010
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange87-90
dc.relation.issn0920-1211
dc.relation.volume129
dc.rights.accesslevelopenAccess


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