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dc.contributor.authorSalo, HM
dc.contributor.authorKoponen, J
dc.contributor.authorKiviranta, H
dc.contributor.authorRantakokko, P
dc.contributor.authorHonkanen, J
dc.contributor.authorHärkönen, T
dc.contributor.authorIlonen, J
dc.contributor.authorVirtanen, SM
dc.contributor.authorTillmann, V
dc.contributor.authorKnip, M
dc.contributor.authorVaarala, O
dc.date.accessioned2018-12-17T13:02:46Z
dc.date.available2018-12-17T13:02:46Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7205
dc.description.abstractExposure to environmental chemicals can modulate the developing immune system, but its role in the pathogenesis of type 1 diabetes is largely unexplored. Our objective was to study the levels of circulating concentrations of environmental pollutants during the first years of life and their associations with the later risk of diabetes-predictive autoantibodies. From two birth-cohort studies including newborn infants with HLA-conferred susceptibility to type 1 diabetes (FINDIA and DIABIMMUNE), we identified case children with at least one biochemical diabetes-associated autoantibody (n = 30–40) and from one to four autoantibody-negative controls per each case child matched for age, gender, diabetes-related HLA-risk, delivery hospital, and, in FINDIA, also dietary intervention group. Plasma levels of 13 persistent organic pollutants and 14 per- and polyfluorinated substances were analyzed in cord blood and plasma samples taken at the age of 12 and 48 months. Both breastfeeding and the geographical living environment showed association with circulating concentrations of some of the chemicals. Breastfeeding-adjusted conditional logistic regression model showed association between decreased plasma HBC concentration at 12-month-old children and the appearance of diabetes-associated autoantibodies (HR, 0.989; 95% Cl, 0.978–1.000; P = 0.048). No association was found between the plasma chemical levels and the development of clinical type 1 diabetes. Our results do not support the view that exposure to the studied environmental chemicals during fetal life or early childhood is a significant risk factor for later development of β-cell autoimmunity and type 1 diabetes.
dc.language.isoenglanti
dc.publisherSpringer Nature America, Inc
dc.relation.ispartofseriesENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
dc.relation.urihttp://dx.doi.org/10.1007/s11356-018-3659-6
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjecthuman
dc.subjectchemical exposure
dc.subjectβ-cell autoimmunity
dc.subjecttype 1 diabetes
dc.subjectbreastfeeding
dc.titleNo evidence of the role of early chemical exposure in the development of ß-cell autoimmunity
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id58564701en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/202063/EU/ Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis/DIABIMMUNE
dc.relation.doi10.1007/s11356-018-3659-6
dc.description.reviewstatuspeerReviewed
dc.publisher.countrySaksa
dc.relation.issn0944-1344
dc.relation.volumeFirst Online: 13 November 2018
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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