Girls and Boys Have a Different Cardiometabolic Response to Obesity Treatment
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CitationDalla Valle, Marketta. Laatikainen, Tiina. Potinkara, Hanna. Nykänen, Päivi. Jääskeläinen, Jarmo. (2018). Girls and Boys Have a Different Cardiometabolic Response to Obesity Treatment. Frontiers in endocrinology, 9, 579. 10.3389/fendo.2018.00579.
Background: Childhood obesity exposes individuals to cardiometabolic disturbances. We analyzed how family-based multidisciplinary obesity treatment influenced children's cardiometabolic health.
Materials and methods: In this retrospective, two-year, follow-up study of 654 2- to 18-year-old children treated for obesity in three Finnish pediatric clinics in 2005–2012, blood pressure (BP), metabolic parameters, and the influence of sex, puberty and a change in body mass index standard deviation score (BMI SDS) were analyzed.
Results: At baseline, at least one cardiovascular risk factor was present in 474 (80%) cases. Boys presented with more significant changes in cardiometabolic parameters than girls during the treatment. Boys' total cholesterol (TC) improved by 12 months (P = 0.009), and their low-density lipoprotein C (LDL-C) and glycosylated hemoglobin ameliorated by 12 months (P = 0.030 and 0.022, respectively) and 24 months (P = 0.043 and 0.025, respectively). Boys' triglycerides, insulin, homeostasis model assessment for insulin resistance (HOMA-IR) and systolic BP deteriorated at 24 months (P < 0.001, 0.004, 0.002, and 0.037, respectively). In all children, the number of acceptable TC, LDL-C, insulin, and HOMA-IR values increased if BMI SDS reduced 0.25 or more by 12 months.
Conclusion: Minor cardiometabolic improvements were found during the obesity treatment. These findings indicate the need to assess treatment methods and focus on prevention.
Subjectschildhood obesity specialist care cardiometabolic treatment outcomes blood pressure fatty liver metabolism BMI SDS
Link to the original itemhttp://dx.doi.org/10.3389/fendo.2018.00579
PublisherFrontiers Media SA
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