dc.contributor.author | Dalla Valle, Marketta | |
dc.contributor.author | Laatikainen, Tiina | |
dc.contributor.author | Potinkara, Hanna | |
dc.contributor.author | Nykänen, Päivi | |
dc.contributor.author | Jääskeläinen, Jarmo | |
dc.date.accessioned | 2019-01-03T12:36:16Z | |
dc.date.available | 2019-01-03T12:36:16Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/7234 | |
dc.description.abstract | Background: Childhood obesity exposes individuals to cardiometabolic disturbances. We analyzed how family-based multidisciplinary obesity treatment influenced children's cardiometabolic health.
Materials and methods: In this retrospective, two-year, follow-up study of 654 2- to 18-year-old children treated for obesity in three Finnish pediatric clinics in 2005–2012, blood pressure (BP), metabolic parameters, and the influence of sex, puberty and a change in body mass index standard deviation score (BMI SDS) were analyzed.
Results: At baseline, at least one cardiovascular risk factor was present in 474 (80%) cases. Boys presented with more significant changes in cardiometabolic parameters than girls during the treatment. Boys' total cholesterol (TC) improved by 12 months (P = 0.009), and their low-density lipoprotein C (LDL-C) and glycosylated hemoglobin ameliorated by 12 months (P = 0.030 and 0.022, respectively) and 24 months (P = 0.043 and 0.025, respectively). Boys' triglycerides, insulin, homeostasis model assessment for insulin resistance (HOMA-IR) and systolic BP deteriorated at 24 months (P < 0.001, 0.004, 0.002, and 0.037, respectively). In all children, the number of acceptable TC, LDL-C, insulin, and HOMA-IR values increased if BMI SDS reduced 0.25 or more by 12 months.
Conclusion: Minor cardiometabolic improvements were found during the obesity treatment. These findings indicate the need to assess treatment methods and focus on prevention. | |
dc.language.iso | englanti | |
dc.publisher | Frontiers Media SA | |
dc.relation.ispartofseries | Frontiers in endocrinology | |
dc.relation.uri | http://dx.doi.org/10.3389/fendo.2018.00579 | |
dc.rights | CC BY 4.0 | |
dc.subject | childhood obesity | |
dc.subject | specialist care | |
dc.subject | cardiometabolic | |
dc.subject | treatment outcomes | |
dc.subject | blood pressure | |
dc.subject | fatty liver | |
dc.subject | metabolism | |
dc.subject | BMI SDS | |
dc.title | Girls and Boys Have a Different Cardiometabolic Response to Obesity Treatment | |
dc.description.version | published version | |
dc.contributor.department | School of Medicine / Public Health | |
dc.contributor.department | School of Medicine / Clinical Medicine | |
uef.solecris.id | 57907368 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.relation.doi | 10.3389/fendo.2018.00579 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 579 | |
dc.publisher.country | Sveitsi | |
dc.relation.articlenumber | 579 | |
dc.relation.volume | 9 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Open access -julkaisukanavassa ilmestynyt julkaisu | |
dc.rights.copyright | © 2018 Authors | |
dc.type.displayType | Artikkeli | fi |
dc.type.displayType | Article | en |
uef.rt.id | 7063 | en |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |