Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults
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CitationHeikkinen, N. Kärkkäinen, O. Laukkanen, E. Kekkonen, V. Kaarre, O. Kivimäki, P. Könönen, M. Velagapudi, V. Nandania, J. Lehto, SM. Niskanen, E. Vanninen, R. Tolmunen, T. (2018). Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults. ALCOHOL, 75, 89-97. 10.1016/j.alcohol.2018.05.010.
Our aim was to analyze metabolite profile changes in serum associated with moderate-to-heavy consumption of alcohol in young adults and to evaluate whether these changes are connected to reduced brain gray matter volumes. These study population consisted of young adults with a 10-year history of moderate-to-heavy alcohol consumption (n = 35) and light-drinking controls (n = 27). We used the targeted liquid chromatography mass spectrometry method to measure concentrations of metabolites in serum, and 3.0 T magnetic resonance imaging to assess brain gray matter volumes. Alterations in amino acid and energy metabolism were observed in the moderate-to-heavy drinking young adults when compared to the controls. After correction for multiple testing, the group of moderate-to-heavy drinking young adults had increased serum concentrations of 1-methylhistamine (p = 0.001, d = 0.82) when compared to the controls. Furthermore, concentrations of 1-methylhistamine (r = −0.48, p = 0.004) and creatine (r = −0.52, p = 0.001) were negatively correlated with the brain gray matter volumes in the females. Overall, our results show association between moderate-to-heavy use of alcohol and altered metabolite profile in young adults as well as suggesting that some of these changes could be associated with the reduced brain gray matter volume.