Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing

Thumbnail
Files
Article (5.536Mb)
Self archived version
final draft
Date
2018
Author(s)
Medarametla, Prasanthi
Gatta, Viviana
Kajander, Tommi
Laitinen, Tuomo
Tammela, Päivi
Poso Antti
Unique identifier
10.1002/cmdc.201800548
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Medarametla, Prasanthi. Gatta, Viviana. Kajander, Tommi. Laitinen, Tuomo. Tammela, Päivi. Poso Antti. (2018). Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing.  CHEMMEDCHEM, 13 (12) , 10.1002/cmdc.201800548.
Rights
© John Wiley & Sons
Licensed under
All rights reserved
Abstract

In the era of increased antibiotic resistance, targeting enzymes involved in bacterial communication (quorum sensing) represents a new strategy to fight bacterial infections. LsrK is a kinase responsible for the phosphorylation of autoinducer‐2, a signaling molecule involved in quorum sensing. Inhibiting LsrK would lead to quorum sensing inactivation and interfere with the pathogenesis. In this study, we built the first LsrK 3D model and performed virtual screening of a locally available database. Selected compounds were tested against LsrK, and the analogue search conducted based on the positive hits led to the identification of low‐micromolar LsrK inhibitors. These results prove the utility of the model and provide the first class of LsrK inhibitors to be further optimized as antivirulence agents.

URI
https://erepo.uef.fi/handle/123456789/7247
Link to the original item
http://dx.doi.org/10.1002/cmdc.201800548
Publisher
Wiley
Collections
  • Terveystieteiden tiedekunta [1281]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap