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dc.contributor.authorNieminen, T
dc.contributor.authorScott, TA
dc.contributor.authorLin, FM
dc.contributor.authorChen, Z
dc.contributor.authorYla-Herttuala, S
dc.contributor.authorMorris, KV
dc.date.accessioned2019-01-09T14:31:07Z
dc.date.available2019-01-09T14:31:07Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7271
dc.description.abstractThe role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making it a promising therapeutic target for activation in ischemic diseases. In this study, we uncover a functional role for two antisense VEGF-A lncRNAs, RP1-261G23.7 and EST AV731492, in transcriptional regulation of VEGF-A during hypoxia. We find here that both lncRNAs are polyadenylated, concordantly upregulated with VEGF-A, localize to the VEGF-A promoter and upstream elements in a hypoxia dependent manner either as a single-stranded RNA or DNA bound RNA, and are associated with enhancer marks H3K27ac and H3K9ac. Collectively, these data suggest that VEGF-A antisense lncRNAs, RP1-261G23.7 and EST AV731492, function as VEGF-A promoter enhancer-like elements, possibly by acting as a local scaffolding for proteins and also small RNAs to tether.
dc.language.isoenglanti
dc.publisherMDPI AG
dc.relation.ispartofseriesNon-Coding RNA
dc.relation.urihttp://dx.doi.org/10.3390/ncrna4040034
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectvascular endothelial growth factor A (VEGF-A)
dc.subjectlong non-coding RNA (lncRNA)
dc.subjecttranscriptional activation
dc.subjectantisense RNA
dc.titleLong Non-Coding RNA Modulation of VEGF-A during Hypoxia
dc.description.versionpublished version
dc.contributor.departmentA.I. Virtanen -instituutti
uef.solecris.id58712703en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.3390/ncrna4040034
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber34
dc.relation.issn2311-553X
dc.relation.issue4
dc.relation.volume4
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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