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dc.contributor.authorLankinen, M
dc.contributor.authorUusitupa, M
dc.contributor.authorSchwab, U
dc.date.accessioned2019-01-09T14:33:34Z
dc.date.available2019-01-09T14:33:34Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7272
dc.description.abstractThe fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. Therefore, it is of great importance to understand the complexity of mechanisms that may modify fatty acid compositions of plasma or tissues. We carried out an extensive literature survey of gene × diet interaction in the regulation of fatty acid compositions. Most of the related studies have been observational studies, but there are also a few intervention trials that tend to confirm that true interactions exist. Most of the studies deal with the desaturase enzyme cluster (FADS1, FADS2) in chromosome 11 and elongase enzymes. We expect that new genetic variants are being found that are linked with the genetic regulation of plasma or tissue fatty acid composition. This information is of great help to understanding the contribution of dietary fatty acids and their endogenic metabolism to the development of some chronic diseases.
dc.language.isoenglanti
dc.publisherMDPI AG
dc.relation.ispartofseriesNutrients
dc.relation.urihttp://dx.doi.org/10.3390/nu10111785
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectfatty acid
dc.subjectdiet
dc.subjectgenotype
dc.subjecthuman
dc.subjectFADS
dc.titleGenes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membrane
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Nutrition
uef.solecris.id58712846en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.3390/nu10111785
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber1785
dc.relation.issn2072-6643
dc.relation.issue11
dc.relation.volume10
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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