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dc.contributor.authorFranceschini, N
dc.contributor.authorGiambartolomei, C
dc.contributor.authorde Vries, PS
dc.contributor.authorFinan, C
dc.contributor.authorBis, JC
dc.contributor.authorHuntley, RP
dc.contributor.authorLovering, RC
dc.contributor.authorTajuddin, SM
dc.contributor.authorWinkler, TW
dc.contributor.authorGraff, M
dc.contributor.authorKavousi, M
dc.contributor.authorDale, C
dc.contributor.authorSmith, AV
dc.contributor.authorHofer, E
dc.contributor.authorvan Leeuwen, EM
dc.contributor.authorNolte, IM
dc.contributor.authorLu, L
dc.contributor.authorScholz, M
dc.contributor.authorSargurupremraj, M
dc.contributor.authorPitkänen, N
dc.contributor.authoret al [Incl Kurl, Sudhir]
dc.date.accessioned2019-01-14T08:36:48Z
dc.date.available2019-01-14T08:36:48Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7286
dc.description.abstractCarotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
dc.language.isoenglanti
dc.publisherSpringer Nature
dc.relation.ispartofseriesNature Communications
dc.relation.urihttp://dx.doi.org/10.1038/s41467-018-07340-5
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id58981147en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41467-018-07340-5
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber5141
dc.relation.issn2041-1723
dc.relation.issue1
dc.relation.volume9
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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