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dc.contributor.authorJussila, Miro-Pekka
dc.contributor.authorRemes, Tiina
dc.contributor.authorAnttonen, Julia
dc.contributor.authorHarila-Saari, Arja
dc.contributor.authorNiinimäki, Jaakko
dc.contributor.authorPokka, Tytti
dc.contributor.authorKoskenkorva, Päivi
dc.contributor.authorSutela, Anna
dc.contributor.authorToiviainen-Sale, Sanna
dc.contributor.authorArikoski, Pekka
dc.contributor.authorRiikonen, Pekka
dc.contributor.authorArola, Mikko
dc.contributor.authorLähteenmäki, Päivi
dc.contributor.authorSirkia, Kirsti
dc.contributor.authorRantala, Heikki
dc.contributor.authorSuo-Palosaari, Maria
dc.contributor.authorOjaniemi, Marja
dc.date.accessioned2019-01-15T09:49:46Z
dc.date.available2019-01-15T09:49:46Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7318
dc.description.abstractPurpose Long-term side effects of the treatments are common in survivors of irradiated pediatric brain tumors. Ionizing radiation in combination with surgery and chemotherapy during childhood may reduce vertebral height and bone mineral density (BMD), and cause growth failure. The aim of this study was to evaluate the late consequences of tumor treatments on vertebrae in survivors of childhood brain tumors. Methods 72 adult survivors (mean age 27.8 years, standard deviation 6.7) of irradiated childhood brain tumor were studied by spinal magnetic resonance imaging (MRI) for vertebral abnormalities from the national cohort of Finland. Patients were treated in five university hospitals in Finland between the years 1970 and 2008. Subject height and weight were measured and body mass index (BMI) was calculated. The morphology and height/depth ratio of the vertebrae in the middle of the kyphotic thoracic curvature (Th8) and lumbar lordosis (L3) were examined. Vertebrae were analyzed by Genant’s semiquantative (SQ) method and spinal deformity index (SDI) was calculated. BMD was measured by using dual X-ray absorptiometry. Results 4.2% (3/72) of the patients had undiagnosed asymptomatic vertebral fracture and 5.6% (4/72) of patients had radiation-induced decreased vertebral body height. Male patients had flatter vertebrae compared with females. Patient age at the time of irradiation, BMI and irradiation area correlated to vertebral morphology differentially in males and females. BMD had no association with the vertebral shape. Patients who had received craniospinal irradiation were shorter than the general population. Conclusion Childhood brain tumor survivors had a high number of vertebral abnormalities in young adulthood. Irradiation was associated with abnormal vertebral morphology and compromised final height. Male gender may predispose vertebrae to the side effects of irradiation.
dc.language.isoenglanti
dc.publisherPublic Library of Science (PLoS)
dc.relation.ispartofseriesPLOS ONE
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0209193
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleLate vertebral side effects in long-term survivors of irradiated childhood brain tumor
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id59562697en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1371/journal.pone.0209193
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumbere0209193
dc.relation.issn1932-6203
dc.relation.issue12
dc.relation.volume13
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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