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dc.contributor.authorPeloso, GM
dc.contributor.authorvan der Lee, SJ
dc.contributor.authorInternational Genomics of Alzheimer's Project (IGAP)
dc.contributor.authorDestefano, AL
dc.contributor.authorSeshardi, S
dc.contributor.authoret al. (incl. Hiltunen, Mikko
dc.contributor.authorHaapasalo, Annakaisa
dc.contributor.authorHelisalmi, Seppo
dc.contributor.authorKoivisto, Anne)
dc.date.accessioned2019-01-17T08:57:57Z
dc.date.available2019-01-17T08:57:57Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7338
dc.description.abstractIntroduction There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger. Results Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P > .7). Discussion Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
dc.relation.urihttp://dx.doi.org/10.1016/j.dadm.2018.08.008
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectgenetics
dc.subjectHDL-C
dc.subjectsingle nucleotide polymorphisms
dc.subjectinstrumental variables
dc.subjectcholesteryl ester transfer protein
dc.titleGenetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Biomedicine
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id59625091en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1016/j.dadm.2018.08.008
dc.description.reviewstatuspeerReviewed
dc.format.pagerange595-598
dc.relation.issn2352-8729
dc.relation.volume10
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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