dc.contributor.author | Peloso, GM | |
dc.contributor.author | van der Lee, SJ | |
dc.contributor.author | International Genomics of Alzheimer's Project (IGAP) | |
dc.contributor.author | Destefano, AL | |
dc.contributor.author | Seshardi, S | |
dc.contributor.author | et al. (incl. Hiltunen, Mikko | |
dc.contributor.author | Haapasalo, Annakaisa | |
dc.contributor.author | Helisalmi, Seppo | |
dc.contributor.author | Koivisto, Anne) | |
dc.date.accessioned | 2019-01-17T08:57:57Z | |
dc.date.available | 2019-01-17T08:57:57Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/7338 | |
dc.description.abstract | Introduction
There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C.
Methods
Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger.
Results
Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P > .7).
Discussion
Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD. | |
dc.language.iso | englanti | |
dc.publisher | Elsevier BV | |
dc.relation.ispartofseries | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | |
dc.relation.uri | http://dx.doi.org/10.1016/j.dadm.2018.08.008 | |
dc.rights | CC BY 4.0 | |
dc.subject | genetics | |
dc.subject | HDL-C | |
dc.subject | single nucleotide polymorphisms | |
dc.subject | instrumental variables | |
dc.subject | cholesteryl ester transfer protein | |
dc.title | Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease | |
dc.description.version | published version | |
dc.contributor.department | School of Medicine / Biomedicine | |
dc.contributor.department | School of Medicine / Clinical Medicine | |
uef.solecris.id | 59625091 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.relation.doi | 10.1016/j.dadm.2018.08.008 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 595-598 | |
dc.relation.issn | 2352-8729 | |
dc.relation.volume | 10 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Open access -julkaisukanavassa ilmestynyt julkaisu | |
dc.rights.copyright | © Authors | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |