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The effect of camelina sativa oil and fish intakes on fatty acid compositions of blood lipid fractions

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Date
2019
Author
Manninen, S
Lankinen, M
de Mello, V
Ågren, J
Laaksonen, D
Schwab, U
Erkkilä, A
Unique identifier
10.1016/j.numecd.2018.10.002
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Citation
Manninen, S. Lankinen, M. de Mello, V. Ågren, J. Laaksonen, D. Schwab, U. Erkkilä, A. (2019). The effect of camelina sativa oil and fish intakes on fatty acid compositions of blood lipid fractions.  NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES, 29 (1) , 51-61. 10.1016/j.numecd.2018.10.002.
Rights
© The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University
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CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Background and aims
Blood lipid fractions serve as objective biomarkers of dietary fat intake. It is unclear which fatty acid pool most accurately reflects the dietary intakes of different n-3 PUFAs. We aimed to investigate the effect of fish and camelina sativa oil (CSO) intakes on fatty acid composition of erythrocyte membranes (EM), plasma phospholipids (PL), cholesteryl esters (CE) and triglycerides (TG). We also aimed to identify the most appropriate blood lipid fraction for assessing n-3 PUFA intake.

Methods and results
Altogether 79 volunteers with impaired glucose metabolism were randomly assigned either to CSO, fatty fish, lean fish or control groups for 12 weeks. Fatty acid compositions of lipid pools were measured by gas chromatography. The proportion of alpha-linolenic acid (ALA) increased in all lipid pools in the CSO group (false discovery rate (FDR) p < 0.001 for all). Similarly, the proportions of EPA and DHA increased in all lipid fractions in the fatty fish group (FDR p < 0.001 for EM, PL and CE; FDR p = 0.005 for TG; FDR p < 0.001 for EM, PL, CE; FDR p < 0.007 for TG, respectively). Changes in the dietary intakes of ALA, EPA and DHA correlated with the changes in their proportions in all lipid pools (r = 0.3–0.5, p < 0.05).

Conclusion
There is no difference in the ability of blood lipid fractions in reflecting the dietary intake of different n-3 PUFAs over a time period of 12 weeks in subjects with high baseline omega-3 index.

Subjects
α-linolenic acid   biomarker   DHA   EPA   erythrocyte membranes   red blood cell membranes   
URI
https://erepo.uef.fi/handle/123456789/7340
Link to the original item
http://dx.doi.org/10.1016/j.numecd.2018.10.002
Publisher
Elsevier BV
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  • Terveystieteiden tiedekunta
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