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dc.contributor.authorRiikonen, Raili
dc.contributor.authorKokki, Hannu
dc.date.accessioned2019-01-18T13:18:08Z
dc.date.available2019-01-18T13:18:08Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7353
dc.description.abstractTuberous sclerosis is associated with epilepsy that is often refractory. We examined cerebrospinal fluid (CSF) concentrations for neurotrophins, nerve growth factor (β-NGF) and insulin-like growth factor (IGF-1) in children with infantile spasms between 1997 and 2010. We classified the patients as follows: tuberous sclerosis (n = 5), cryptogenic spasms (n = 6), postinfectious spasms (n = 5) and other symptomatic spasms (n = 22). We had 22 age- and sex-matched controls for CSF-NGF and 14 for CSF-IGF-1. The median of CSF-NGF was higher in those with tuberous sclerosis, 56 (minimum–maximum, 8.0–131) ng/L, in relative to age- and sex-matched controls, 6.7 (0.0–22) ng/L, and symptomatic infantile spasms, 0.0 (0.0–4.5) ng/L or cryptogenic cases of infantile spasms, 6.2 (3.9–8.8) ng/L, respectively. CSF-NGF were highest in children with postinfectious aetiology, 408 (89–778) ng/L. CSF-IGF-1 of tuberous sclerosis, 0.65 (0.35–0.98) μg/L, did not differ from the cryptogenic spasms, 0.68 (0.32–0.87) μg/L, or from age- and sex-matched controls 0.52 (0.22–0.77) μg/L. Patients with tuberous sclerosis and cryptogenic spasms had normal development prior the ACTH therapy. We suggest that increased CSF-NGF might indicate a persistent activation of inflammatory pathways in cortical tubers in tuberous sclerosis and this would reflect in CSF concentrations.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesEUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
dc.relation.urihttp://dx.doi.org/10.1016/j.ejpn.2018.11.001
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjecttuberous sclerosis
dc.subjectnerve growth facto
dc.subjectinsulin-like growth factor
dc.subjectinfantile spasms
dc.titleCSF nerve growth factor (ß-NGF) is increased but CSF insulin-like growth factor-(IGF-1) is normal in children with tuberous sclerosis and infantile spasms
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id59040859en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Ltd on behalf of European Paediatric Neurology Society.
dc.relation.doi10.1016/j.ejpn.2018.11.001
dc.description.reviewstatuspeerReviewed
dc.format.pagerange191-196
dc.relation.issn1090-3798
dc.relation.issue1
dc.relation.volume23
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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