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dc.contributor.authorPoon, Charissa T
dc.contributor.authorShah, Kairavi
dc.contributor.authorLin, Chiungting
dc.contributor.authorTse, Ryan
dc.contributor.authorKim, Kate K
dc.contributor.authorMooney, Skyler
dc.contributor.authorAubert, Isabelle
dc.contributor.authorStefanovic, Bojana
dc.contributor.authorHynynen, Kullervo
dc.date.accessioned2019-01-23T14:04:54Z
dc.date.available2019-01-23T14:04:54Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7368
dc.description.abstractPrevious studies have demonstrated that temporarily increasing the permeability of the blood-brain barrier using focused ultrasound can reduce β-amyloid plaque load and improve cognitive function in animal models of Alzheimer’s disease. However, the underlying mechanism and duration for which the effects of one treatment persists for are unknown. Here, we used in vivo two-photon fluorescence microscopy to track changes in β-amyloid plaque sizes in the TgCRND8 mouse model of Alzheimer’s disease after one focused ultrasound treatment. We found that one treatment reduced plaques to 62 ± 16% (p ≤ 0.001) of their original volume two days post-sonication; this decrease in size persisted for two weeks. We then sought to evaluate the effectiveness of biweekly focused ultrasound treatments using magnetic resonance imaging-guided focused ultrasound treatments. Three to five biweekly treatments resulted in a 27 ± 7% (p ≤ 0.01) decrease in plaque number and 40 ± 10% (p ≤ 0.01) decrease in plaque surface area compared to untreated littermates. This study demonstrates that one focused ultrasound treatment reduces the size of existing β-amyloid plaques for two weeks, and that repeated biweekly focused ultrasound treatments is an effective method of reducing β-amyloid pathology in moderate-to-late stages of Alzheimer’s disease.
dc.language.isoenglanti
dc.publisherSpringer Nature America, Inc
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://dx.doi.org/10.1038/s41598-018-32250-3
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleTime course of focused ultrasound effects on beta-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease
dc.description.versionpublished version
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id59655538en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41598-018-32250-3
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber14061
dc.relation.issn2045-2322
dc.relation.volume8
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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