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dc.contributor.authorO'Reilly, Meaghan A
dc.contributor.authorChinnery, Tricia
dc.contributor.authorYee, My-Linh
dc.contributor.authorWu, Sheng-Kai
dc.contributor.authorHynynen, Kullervo
dc.contributor.authorKerbel, Robert S
dc.contributor.authorCzarnota, Gregory J
dc.contributor.authorPritchard, Kathleen I: Sahgal, Arjun
dc.date.accessioned2019-01-23T14:17:22Z
dc.date.available2019-01-23T14:17:22Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7372
dc.description.abstractLeptomeningeal metastases (LM) are a serious complication of cancer in the central nervous system (CNS) and are diagnosed in approximately 5% of patients with solid tumors. Effective treatment using systemically administered therapeutics is hindered by the barriers of the CNS. Ultrasound can mediate delivery of drugs through these barriers. The goal of this study was to test the feasibility of using ultrasound-mediated drug delivery to improve the treatment of LM. LM was induced in the spinal cord of athymic rats by injecting HER2-expressing breast cancer cells into the subarachnoid space of the thoracic spine. Animals were divided into three groups: no treatment (n = 5), trastuzumab only (n = 6) or trastuzumab + focused ultrasound + microbubbles (FUS + MBs) (n = 7). Animals in groups 2 and 3 were treated weekly with intravenous trastuzumab +/− FUS + MBs for three weeks. Suppression in tumor growth was qualitatively observed by MRI in the group receiving ultrasound, and was confirmed by a significant difference in the tumor volume measured from the histology data (25 ± 17 mm3 vs 8 ± 5 mm3, p = 0.04 in the trastuzumab-only vs trastuzumab + FUS + MBs). This pilot study demonstrates the potential of ultrasound-mediated drug delivery as a novel treatment for LM. Future studies will extend this work to larger cohorts and the investigation of LM arising from other cancers.
dc.language.isoenglanti
dc.publisherSpringer Nature
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://dx.doi.org/10.1038/s41598-018-27335-y
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titlePreliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases
dc.description.versionpublished version
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id59655821en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41598-018-27335-y
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber9013
dc.relation.issn2045-2322
dc.relation.volume8
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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