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dc.contributor.authorVanhala, V
dc.contributor.authorJunkkari, A
dc.contributor.authorKorhonen, VE
dc.contributor.authorKurki, MI
dc.contributor.authorHiltunen, M
dc.contributor.authorRauramaa, T;, Nerg, O;, Koivisto, AM
dc.contributor.authorRemes, AM
dc.contributor.authorPerälä, J
dc.contributor.authorSuvisaari, J
dc.contributor.authorLehto, S
dc.contributor.authorViinamäki, H
dc.contributor.authorSoininen, H
dc.contributor.authorJääskeläinen, JE
dc.contributor.authorLeinonen, V
dc.date.accessioned2019-02-15T13:12:32Z
dc.date.available2019-02-15T13:12:32Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7447
dc.description.abstractBACKGROUND Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and potentially treatable neurodegenerative disease affecting elderly people, characterized by gait impairment and ventricular enlargement in brain imaging. Similar findings are seen in some patients with schizophrenia (SCZ). OBJECTIVE To determine the prevalence of SCZ among patients suffering from probable or possible iNPH and the specific effects of comorbid SCZ on the outcome of the cerebrospinal fluid (CSF) shunting. METHODS All medical records of the 521 iNPH patients in the NPH registry were retrospectively analyzed from 1991 until 2017. The prevalence of comorbidity of SCZ was determined and compared to that of general aged (≥65 yr) population in Finland. RESULTS We identified a total of 16 (3.1%) iNPH patients suffering from comorbid SCZ. The prevalence of SCZ among the iNPH patients was significantly higher compared to the general population (3.1% vs 0.9%, P < .001). All iNPH patients with comorbid SCZ were CSF shunted and 12 (75%) had a clinically verified shunt response 3 to 12 mo after the procedure. The CSF shunt response rate did not differ between patients with and without comorbid SCZ. CONCLUSION SCZ seems to occur 3 times more frequently among iNPH patients compared to the general aged population in Finland. The outcome of the treatment was not affected by comorbid SCZ and therefore iNPH patients suffering from comorbid SCZ should not be left untreated. These results merit validation in other populations. In addition, further research towards the potential connection between these chronic conditions is warranted.
dc.language.isoenglanti
dc.publisherOxford University Press (OUP)
dc.relation.ispartofseriesNEUROSURGERY
dc.relation.urihttp://dx.doi.org/10.1093/neuros/nyy147
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePrevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id60387981en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Congress of Neurological Surgeons
dc.relation.doi10.1093/neuros/nyy147
dc.description.reviewstatuspeerReviewed
dc.format.pagerange883-889
dc.relation.issn0148-396X
dc.relation.issue4
dc.relation.volume84
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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