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dc.contributor.authorPyysalo, Mika
dc.contributor.authorPyysalo, Liisa
dc.contributor.authorHiltunen, Jenni
dc.contributor.authorJärnstedt, Jorma
dc.contributor.authorHelminen, Mika
dc.contributor.authorKarhunen, Pekka
dc.contributor.authorPessi, Tanja
dc.date.accessioned2019-02-15T13:22:25Z
dc.date.available2019-02-15T13:22:25Z
dc.date.issued2018
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7449
dc.description.abstractObjective Dental bacterial DNA and bacterial-driven inflammation markers have previously been detected in intracranial aneurysm tissue samples. This study aimed (i) to assess the possible presence of dental infectious foci, (ii) and the possible association between typical odontogenic bacteria and clinical dental findings in patients undergoing pre-operative dental examination before surgical treatment of saccular intracranial aneurysm. Ninety patients with an intracranial aneurysm were recruited to the study, and the patients’ teeth were routinely investigated. Clinical data and bacterial samples from the gingival pockets were collected from a subpopulation of 60 patients. Five typical dental pathogens and total bacteria amounts were measured from gingival samples using real-time quantitative PCR. Results The amounts of total bacterial and Fusobacterium nucleatum DNA were significantly higher in the patients with ≥ 6 mm gingival pockets than patients without them (p < 0.01 and p < 0.01, respectively). A total of 43% of patients with an aneurysm had gingival pockets of 6 mm or deeper. Dental infectious foci are fairly common in the Finnish population, with the prevalence of severe periodontitis being around 20%. The frequency of chronic dental infections, especially periodontitis seems to be higher in patients with intracranial aneurysm.
dc.language.isoenglanti
dc.publisherSpringer Nature America, Inc
dc.relation.ispartofseriesBMC RESEARCH NOTES
dc.relation.urihttp://dx.doi.org/10.1186/s13104-018-3704-z
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectintracranial aneurysm
dc.subjectoral health
dc.subjectinflammation
dc.subjectperiodontitis
dc.subjectbacteria
dc.subjectqPCR
dc.subjectbacterial DNA
dc.subjectfusobacteria
dc.titleThe dental infections in patients undergoing preoperative dental examination before surgical treatment of saccular intracranial aneurysm
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id60418384en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1186/s13104-018-3704-z
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber600
dc.relation.volume11
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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