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dc.contributor.authorTajik, Behnam
dc.contributor.authorKurl, Sudhir
dc.contributor.authorTuomainen, Tomi-Pekka
dc.contributor.authorVirtanen, Jyrki K
dc.date.accessioned2019-02-19T11:45:44Z
dc.date.available2019-02-19T11:45:44Z
dc.date.issued2016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7459
dc.description.abstractPurpose Long-chain omega-3 polyunsaturated fatty acids (PUFA) from fish have been associated with risk of cardiovascular diseases (CVD), especially sudden cardiac death (SCD). Mercury exposure, mainly due fish consumption, has been associated with higher risk. However, the impact of PUFAs or mercury on the ventricular cardiac arrhythmias, which often precede SCD, is not completely known. We investigated the associations of the serum long-chain omega-3 PUFAs and hair mercury with ventricular repolarization, measured by heart rate-corrected QT and JT intervals (QTc and JTc, respectively). Methods A total of 1411 men from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study, aged 42–60 years and free of CVD in 1984–1989, were studied. Results Serum long-chain omega-3 PUFA concentrations were inversely associated with QTc and JTc (multivariate-adjusted P trend across quartiles = 0.02 and 0.002, respectively) and, during the mean 22.9-year follow-up, with lower SCD risk. However, further adjustments for QTc, JTc or hair mercury did not attenuate the associations with SCD. Hair mercury was not associated with QTc, JTc or SCD risk, but it slightly attenuated the associations of the serum long-chain omega-3 PUFA with QTc and JTc. Conclusions Higher serum long-chain omega-3 PUFA concentrations, mainly a marker for fish consumption, were inversely associated with QTc and JTc in middle-aged and older men from Eastern Finland, but QTc or JTc did not attenuate the inverse associations of the long-chain omega-3 PUFA with SCD risk. This suggests that prevention of prolonged ventricular repolarization may not explain the inverse association of the long-chain omega-3 PUFA with SCD risk.en
dc.language.isoenglantien
dc.publisherSpringer International Publishingen
dc.relation.ispartofseriesEuropean journal of nutritionen
dc.relation.urihttp://dx.doi.org/10.1007/s00394-016-1272-3en
dc.rightsAll rights reserveden
dc.subjectpolyunsaturated fatty acidsen
dc.subjectheart electrophysiologyen
dc.subjectQT intervalen
dc.subjectmethylmercuryen
dc.subjectpopulation studyen
dc.titleAssociations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury with heart rate-corrected QT and JT intervals in men: the Kuopio Ischaemic Heart Disease Risk Factor Studyen
dc.description.versionfinal draften
dc.contributor.departmentLääketieteen laitos / Kliininen lääketiedeen
uef.solecris.id42542997en
dc.type.publicationarticleen
dc.rights.accessrights© Springer-Verlag Berlin Heidelbergen
dc.relation.doi10.1007/s00394-016-1272-3en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange2319-2327en
dc.relation.issn1436-6207en
dc.relation.issue7en
dc.relation.volume56en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen


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