dc.contributor.author | Hooshmand, B | |
dc.contributor.author | Rusanen, M | |
dc.contributor.author | Ngandu, T | |
dc.contributor.author | Leiviskä, J | |
dc.contributor.author | Sindi, S | |
dc.contributor.author | von Arnim, CAF | |
dc.contributor.author | Falkai, P | |
dc.contributor.author | Soininen, H | |
dc.contributor.author | Tuomilehto, J | |
dc.contributor.author | Kivipelto, M | |
dc.date.accessioned | 2019-03-28T09:12:53Z | |
dc.date.available | 2019-03-28T09:12:53Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/7507 | |
dc.description.abstract | Purpose
The aim of this study was to examine the association of serum glucose, insulin, and insulin resistance with cognitive functioning 7 years later in a longitudinal population-based study of Finnish older adults.
Methods
Serum glucose and insulin were measured at baseline in 269 dementia-free individuals aged 65-79 years, from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study. Insulin resistance was estimated with the homeostasis model assessment (HOMA-IR). Participants were reexamined 7 years later, and global cognition, episodic memory, executive functioning, verbal expression, and psychomotor speed were assessed, both at baseline and at follow-up. Multiple linear regression was used to investigate the associations with cognitive performance at follow-up, after adjusting for several potential confounders, including common vascular risk factors.
Results
In the multivariable-adjusted linear regression models, no associations of insulin resistance with cognitive functioning were observed. After excluding 19 incident dementia cases, higher baseline HOMA-IR values were related to worse performance in global cognition (β [standard error (SE)] -.050 [0.02]; P = .043) and psychomotor speed (β [SE] -.064 [.03]; P = [.043]) 7 years later. Raised serum insulin levels were associated with lower scores on global cognition (β [SE] -.054 [.03]; P = .045) and tended to relate to poorer performance in psychomotor speed (β [SE] -.061 [.03]; P = .070).
Conclusions
Serum insulin and insulin resistance may be independent predictors of cognitive performance 7 years later in elderly individuals without dementia. Randomized controlled trials are needed to determine this issue. | |
dc.language.iso | englanti | |
dc.publisher | Elsevier BV | |
dc.relation.ispartofseries | American journal of medicine | |
dc.relation.uri | http://dx.doi.org/10.1016/j.amjmed.2018.11.013 | |
dc.rights | CC BY-NC-ND 4.0 | |
dc.subject | cognition | |
dc.subject | dementia | |
dc.subject | insulin | |
dc.subject | insulin resistance | |
dc.title | Serum insulin and cognitive performance in older adults: a longitudinal study | |
dc.description.version | final draft | |
dc.contributor.department | School of Medicine / Clinical Medicine | |
uef.solecris.id | 59040880 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.relation.doi | 10.1016/j.amjmed.2018.11.013 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 367-373 | |
dc.relation.issn | 0002-9343 | |
dc.relation.issue | 3 | |
dc.relation.volume | 132 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Ei | |
dc.rights.copyright | © Elsevier Inc | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |