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dc.contributor.authorDekel, S
dc.contributor.authorEin-Dor, T
dc.contributor.authorRuohomäki, A
dc.contributor.authorLampi, J
dc.contributor.authorVoutilainen, S
dc.contributor.authorTuomainen, TP
dc.contributor.authorHeinonen, S
dc.contributor.authorKumpulainen, K
dc.contributor.authorPekkanen, J
dc.contributor.authorKeski-Nisula, L
dc.contributor.authorPasanen, M
dc.contributor.authorLehto, SM
dc.date.accessioned2019-04-29T08:34:46Z
dc.date.available2019-04-29T08:34:46Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7574
dc.description.abstractObjective Peripartum depression (PPD) pertaining to depression in pregnancy and postpartum is one of the most common complications around childbirth with enduring adverse effects on mother and child health. Although psychiatric symptoms may improve or worsen over time, relatively little is known about the course of PPD symptoms and possible fluctuations. Methods We applied a person-centered approach to examine PPD symptom patterns across pregnancy and childbirth. 824 women were assessed at three time points: first trimester (T1), third trimester (T2), and again at eight weeks (T3) postpartum. We assessed PPD symptoms, maternal mental health history, and childbirth variables. Results Growth mixture modeling (GMM) analysis revealed four discrete PPD symptom trajectory classes including chronic PPD (1.1%), delayed (10.2%), recovered (7.2%), and resilient (81.5%). Delivery complications were associated with chronic PPD but also with the recovered PPD trajectory class. History of mental health disorders was associated with chronic PPD and the delayed PPD class. Conclusion The findings underscore that significant changes in a woman's depression level can occur across pregnancy and childbirth. While a minority of women experience chronic PDD, for others depression symptoms appear to significantly alleviate over time, suggesting a form of recovery. Our findings support a personalized medicine approach based on the woman's symptom trajectory. Future research is warranted to identify the mechanisms underlying modifications in PPD symptoms severity and those implicated in recovery.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesJournal of psychiatric research
dc.relation.urihttp://dx.doi.org/10.1016/j.jpsychires.2019.03.016
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectperipartum depression
dc.subjectchildbirth
dc.subjectprospective sample
dc.subjectsymptom trajectory
dc.subjectgrowth modeling
dc.titleThe dynamic course of peripartum depression across pregnancy and childbirth
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
dc.contributor.departmentSchool of Medicine / Clinical Nutrition,School of Pharmacy, Activities,School of Medicine / Public Health
uef.solecris.id61495002en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Ltd.
dc.relation.doi10.1016/j.jpsychires.2019.03.016
dc.description.reviewstatuspeerReviewed
dc.format.pagerange72-78
dc.relation.issn0022-3956
dc.relation.volume113
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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