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dc.contributor.authorRenko, Marjo
dc.contributor.authorLantto, Ulla
dc.contributor.authorTapiainen, Terhi
dc.date.accessioned2019-04-29T08:51:02Z
dc.date.available2019-04-29T08:51:02Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7575
dc.description.abstractAim Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most common cause of a periodic fever in childhood. The exact pathogenesis and the aetiology of PFAPA are still unknown. Methods We conducted a non‐systematic review of published articles about PFAPA syndrome and summarised the evidence for diagnostic criteria and treatment options for PFAPA. Results The first proposed diagnostic criteria for PFAPA, in addition to periodic fever, included aphthous stomatitis, pharyngitis or cervical lymphadenitis in children younger than five years at the beginning of the symptoms. C‐reactive protein (CRP) levels and leucocyte counts increase in most patients during episodes. Recent research reveals that tonsillectomy provides an immediate and long‐lasting cure for PFAPA, even in the absence of classic criteria of aphthous stomatitis, pharyngitis or cervical adenitis and in children older than five years. Conclusion We suggest that PFAPA can be diagnosed in children with at least five regularly occurring fever episodes without any other explanation, even in the absence of aphthous stomatitis, pharyngitis or cervical lymphadenitis and also in children older than five years.
dc.language.isoenglanti
dc.publisherWiley
dc.relation.ispartofseriesActa paediatrica
dc.relation.urihttp://dx.doi.org/10.1111/apa.14792
dc.rightsAll rights reserved
dc.subjectaphthas
dc.subjectautoinflammatory disease
dc.subjectrecurrent fever
dc.subjectregularity
dc.subjecttonsillectomy
dc.titleTowards better diagnostic criteria for PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) syndrome
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id61309520en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Foundation Acta Pædiatrica
dc.relation.doi10.1111/apa.14792
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1385-1392
dc.relation.issn0803-5253
dc.relation.issue8
dc.relation.volume108
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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