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dc.contributor.authorMyhrstad, MC
dc.contributor.authorde Mello, VD
dc.contributor.authorDahlman, I
dc.contributor.authorKolehmainen, M
dc.contributor.authorPaananen, J
dc.contributor.authorRundblad, A
dc.contributor.authorCarlberg, C
dc.contributor.authorOlstad, OK
dc.contributor.authorPihlajamäki, J
dc.contributor.authorHolven, KB
dc.contributor.authorHermansen, K
dc.contributor.authorDragsted, LO
dc.contributor.authorGunnarsdottir, I
dc.contributor.authorCloetens, L
dc.contributor.authorStorm, MU
dc.contributor.authorÅkesson, B
dc.contributor.authorRosqvist, F
dc.contributor.authorHukkanen, J
dc.contributor.authoret al. (incl. Schwab, U
dc.contributor.authorUusitupa, M)
dc.date.accessioned2019-05-08T11:19:53Z
dc.date.available2019-05-08T11:19:53Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7591
dc.description.abstractScope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p‐value < 0.05). Twenty‐five of these are significantly regulated (FDR q‐value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF‐κB, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.
dc.language.isoenglanti
dc.publisherWiley
dc.relation.ispartofseriesMolecular nutrition and food research
dc.relation.urihttp://dx.doi.org/10.1002/mnfr.201801405
dc.rightsAll rights reserved
dc.subjectgene‐expression
dc.subjecthealthy Nordic diet
dc.subjectmetabolic syndrome
dc.subjectperipheral blood mononuclear cells
dc.subjecttranscripto
dc.titleHealthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Nutrition
dc.contributor.departmentSchool of Medicine / Biomedicine
uef.solecris.id61680808en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.relation.doi10.1002/mnfr.201801405
dc.description.reviewstatuspeerReviewed
dc.publisher.countrySaksa
dc.relation.articlenumber1801405
dc.relation.issn1613-4125
dc.relation.issue13
dc.relation.volume63
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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