Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Prognostic Value of Preoperative Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Epithelial Ovarian Cancer

Thumbnail
Files
Article (996.9Kb)
Self archived version
final draft
Date
2019
Author(s)
Lindgren, Auni
Anttila, Maarit
Arponen, Otso
Rautiainen, Suvi
Könönen, Mervi
Vanninen, Ritva
Sallinen, Hanna
Unique identifier
10.1016/j.ejrad.2019.03.023
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Lindgren, Auni. Anttila, Maarit. Arponen, Otso. Rautiainen, Suvi. Könönen, Mervi. Vanninen, Ritva. Sallinen, Hanna. (2019). Prognostic Value of Preoperative Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Epithelial Ovarian Cancer.  European journal of radiology, 115, 66-73. 10.1016/j.ejrad.2019.03.023.
Rights
© Elsevier B.V.
Licensed under
CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Objectives
To investigate whether semi-quantitative and pharmacokinetic perfusion dynamic contrast-enhanced (DCE) parameters are associated with traditional prognostic factors and can predict clinical outcome in ovarian cancer (OC).

Methods
This prospective study, approved by local ethical committee, enrolled 38 patients with primary OC, 2011–2014. After preoperative DCE-MRI (3.0 T), two observers measured perfusion (Ktrans, Kep, Ve, Vp) and semi-quantitative parameters (area under the curve, peak, time-to-peak) by drawing regions of interest (ROIs) covering the large solid lesion (L-ROI) and the most enhancing small area (S-ROI) (NordicICE platform). Kruskal–Wallis was used to analyze associations between MRI parameters and classified prognostic factors.

Results
Mean Ktrans values were higher in high-grade serous OC than in other types (L-ROI, P = 0.041; S-ROI, P = 0.018), and lower mean Ktrans values predicted residual tumor (L-ROI P = 0.030; S-ROI, P = 0.012). Higher minimum Vp values were associated with higher International Federation of Gynecology and Obstetrics (FIGO) stage (S-ROI, P = 0.023).Shorter recurrence-free survival was predicted by higher Ve (minimum L-ROI, P = 0.035; maximum S-ROI, P = 0.046), Vp (maximum S-ROI, P = 0.033), and lower time-to-peak (maximum S-ROI, P = 0.047) in Kaplan–Meier analysis. Multiparametric MRI variables combining DCE and diffusion weighted data were also predictive for survival.

Conclusion
DCE-MRI parameters may represent imaging biomarkers for predicting tumor aggressiveness and prognosis in OC. Higher Ktrans levels were associated with better results in cytoreductive surgery but with earlier recurrence.

Subjects
ovarian cancer   magnetic resonance imaging   dynamic contrast-enhanced imaging   biomarkers   prognosis   
URI
https://erepo.uef.fi/handle/123456789/7629
Link to the original item
http://dx.doi.org/10.1016/j.ejrad.2019.03.023
Publisher
Elsevier BV
Collections
  • Terveystieteiden tiedekunta [1336]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap