Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT121 Mice

Thumbnail
Files
Article (3.768Mb)
Self archived version
final draft
Date
2019
Author(s)
Fleet, JC
Kovalenko, PL
Li, Y
Smolinski, J
Spees, C
Yu, JG
Thomas-Ahner, JM
Cui, M
Neme, A
Carlberg, C
Clinton, SK
Unique identifier
10.1158/1940-6207.CAPR-18-0401
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Fleet, JC. Kovalenko, PL. Li, Y. Smolinski, J. Spees, C. Yu, JG. Thomas-Ahner, JM. Cui, M. Neme, A. Carlberg, C. Clinton, SK. (2019). Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT121 Mice.  Cancer prevention research, Published May 14, 2019, 10.1158/1940-6207.CAPR-18-0401.
Rights
© American Association for Cancer Research
Licensed under
All rights reserved
Abstract

We tested whether lifelong modification of vitamin D signaling can alter the progression of early prostate carcinogenesis in studies using mice that develop high-grade prostatic intraepithelial neoplasia that is similar to humans. Two tissue-limited models showed that prostate vitamin D receptor (VDR) loss increased prostate carcinogenesis. In another study, we fed diets with three vitamin D3 levels (inadequate = 25 IU/kg diet, adequate for bone health = 150 IU/kg, or high = 1,000 IU/kg) and two calcium levels (adequate for bone health = 0.5% and high = 1.5%). Dietary vitamin D caused a dose-dependent increase in serum 25-hydroxyvitamin D levels and a reduction in the percentage of mice with adenocarcinoma but did not improve bone mass. In contrast, high calcium suppressed serum 1,25-dihydroxyvitamin D levels and improved bone mass but increased the incidence of adenocarcinoma. Analysis of the VDR cistrome in RWPE1 prostate epithelial cells revealed vitamin D–mediated regulation of multiple cancer-relevant pathways. Our data support the hypothesis that the loss of vitamin D signaling accelerates the early stages of prostate carcinogenesis, and our results suggest that different dietary requirements may be needed to support prostate health or maximize bone mass.

Subjects
diet   calcium   vitamin D receptor   prevention   carcinogenesis   
URI
https://erepo.uef.fi/handle/123456789/7631
Link to the original item
http://dx.doi.org/10.1158/1940-6207.CAPR-18-0401
Publisher
American Association for Cancer Research (AACR)
Collections
  • Terveystieteiden tiedekunta [1336]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap