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dc.contributor.authorNivukoski, U
dc.contributor.authorBloigu, A
dc.contributor.authorBloigu, R
dc.contributor.authorAalto, M
dc.contributor.authorLaatikainen, T
dc.contributor.authorNiemelä, O
dc.date.accessioned2019-06-18T11:18:56Z
dc.date.available2019-06-18T11:18:56Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7642
dc.description.abstractBackground While alcohol use is linked with a wide variety of health problems, the question of whether differences in drinking patterns could yield different outcomes has remained unclear. Patients and methods We measured liver enzymes (ALT, GGT) from alcohol consumers with or without binge drinking from a population-based sample in Finland, where binge-type drinking is common. Data on alcohol use, diet, body weight, lifestyle (smoking, coffee consumption, physical activity), and health status were collected from 19225 subjects (9492 men, 9733 women), aged 25–74 years. The participants were subsequently classified to subgroups, both according to the frequencies of binge drinking and the amounts of regular alcohol intake (low-, medium-, and high-risk drinking). Results The quantity of regular alcohol use was roughly linearly related with GGT and ALT activities. ANOVA analyses of the trends according to the frequency of binge drinking showed a significant GGT increase in both men (p < 0.0005) and women (p < 0.0005), and a significant increase of ALT in men (p < 0.0005). In those with low-risk overall consumption, markedly higher GGT (p < 0.0005) and ALT (p < 0.0005) occurred in those with binge drinking more than once a month, compared with those with no such occasions. Binge drinking occurring ≤1/month also resulted in higher GGT (p < 0.0005) and ALT (p < 0.05) activities. Conclusions These results emphasize possible adverse consequences of binge drinking on hepatic function even in those with low-risk overall consumption. The pattern of drinking should be more systematically implicated in clinical recommendations for drinking reduction.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesAlcohol
dc.relation.urihttp://dx.doi.org/10.1016/j.alcohol.2019.03.001
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectALT
dc.subjectethanol
dc.subjectdrinking pattern
dc.subjectGGT
dc.subjectharm reduction
dc.titleLiver enzymes in alcohol consumers with or without binge drinking
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Public Health
uef.solecris.id61248769en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Inc
dc.relation.doi10.1016/j.alcohol.2019.03.001
dc.description.reviewstatuspeerReviewed
dc.format.pagerange13-19
dc.relation.issn0741-8329
dc.relation.volume78
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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