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IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling

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Date
2019
Author(s)
Kaiser Manjur, ABM
Lempiäinen, Joanna K
Malinen, Marjo
Palvimo, Jorma J
Niskanen, Einari A
Unique identifier
10.1016/j.jsbmb.2019.105382
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Citation
Kaiser Manjur, ABM. Lempiäinen, Joanna K. Malinen, Marjo. Palvimo, Jorma J. Niskanen, Einari A. (2019). IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling.  Journal of steroid biochemistry and molecular biology, 192, 105382. 10.1016/j.jsbmb.2019.105382.
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© Elsevier Ltd
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CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

IRF2BP2 (interferon regulatory factor-2 binding protein-2) is an uncharacterized interaction partner of glucocorticoid (GC) receptor (GR), an anti-inflammatory and metabolic transcription factor. Here, we show that GC changes the chromatin binding of IRF2BP2 in natural chromatin milieu. The GC-induced IRF2BP2-binding sites co-occur with GR binding sites and are associated with GC-induced genes. Moreover, the depletion of IRF2BP2 modulates transcription of GC-regulated genes, represses cell proliferation and increases cell movement in HEK293 cells. In A549 cells, the depletion extensively alters the responses to GC and tumor necrosis factor α (TNF), including metabolic and inflammatory pathways. Taken together, our data support the role of IRF2BP2 as a coregulator of both GR and NF-κB, potentially modulating the crosstalk between GC and TNF signaling.

Subjects
glucocorticoid receptor (GR)   interferon regulatory factor-2 binding protein-2 (IRF2BP2)   nuclear factor-κB (NF-κB)   dexamethasone   tumor necrosis factor α (TNF)   
URI
https://erepo.uef.fi/handle/123456789/7658
Link to the original item
http://dx.doi.org/10.1016/j.jsbmb.2019.105382
Publisher
Elsevier BV
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  • Terveystieteiden tiedekunta [1331]
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