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dc.contributor.authorKaiser Manjur, ABM
dc.contributor.authorLempiäinen, Joanna K
dc.contributor.authorMalinen, Marjo
dc.contributor.authorPalvimo, Jorma J
dc.contributor.authorNiskanen, Einari A
dc.date.accessioned2019-07-03T07:09:35Z
dc.date.available2019-07-03T07:09:35Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7658
dc.description.abstractIRF2BP2 (interferon regulatory factor-2 binding protein-2) is an uncharacterized interaction partner of glucocorticoid (GC) receptor (GR), an anti-inflammatory and metabolic transcription factor. Here, we show that GC changes the chromatin binding of IRF2BP2 in natural chromatin milieu. The GC-induced IRF2BP2-binding sites co-occur with GR binding sites and are associated with GC-induced genes. Moreover, the depletion of IRF2BP2 modulates transcription of GC-regulated genes, represses cell proliferation and increases cell movement in HEK293 cells. In A549 cells, the depletion extensively alters the responses to GC and tumor necrosis factor α (TNF), including metabolic and inflammatory pathways. Taken together, our data support the role of IRF2BP2 as a coregulator of both GR and NF-κB, potentially modulating the crosstalk between GC and TNF signaling.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesJournal of steroid biochemistry and molecular biology
dc.relation.urihttp://dx.doi.org/10.1016/j.jsbmb.2019.105382
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectglucocorticoid receptor (GR)
dc.subjectinterferon regulatory factor-2 binding protein-2 (IRF2BP2)
dc.subjectnuclear factor-κB (NF-κB)
dc.subjectdexamethasone
dc.subjecttumor necrosis factor α (TNF)
dc.titleIRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Biomedicine
dc.contributor.departmentYmpäristö- ja biotieteiden laitos / Toiminta
uef.solecris.id62718660en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Ltd
dc.relation.doi10.1016/j.jsbmb.2019.105382
dc.description.reviewstatuspeerReviewed
dc.format.pagerange105382
dc.relation.issn0960-0760
dc.relation.volume192
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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