Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
Tiedosto(t)
Rinnakkaistallenteen versio
final draftPäivämäärä
2019Tekijä(t)
Asquith, CRM
Meili, T
Laitinen, T
Baranovsky, IV
Konstantinova, LS
Poso, A
Rakitin, OA
Hofmann-Lehmann, R
Yksilöllinen tunniste
10.1016/j.bmcl.2019.05.016Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Asquith, CRM. Meili, T. Laitinen, T. Baranovsky, IV. Konstantinova, LS. Poso, A. Rakitin, OA. Hofmann-Lehmann, R. (2019). Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection. Bioorganic and medicinal chemistry letters, 29 (14) , 1765-1768. 10.1016/j.bmcl.2019.05.016.Oikeudet
© Elsevier Ltd
Tiivistelmä
We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.
Avainsanat
feline immunodeficiency virus (FIV) human immunodeficiency virus (HIV) selenium zinc ejection nucleocapsid protein
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1016/j.bmcl.2019.05.016Julkaisija
Elsevier BVKokoelmat
- Terveystieteiden tiedekunta [1735]