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dc.contributor.authorAsquith, CRM
dc.contributor.authorMeili, T
dc.contributor.authorLaitinen, T
dc.contributor.authorBaranovsky, IV
dc.contributor.authorKonstantinova, LS
dc.contributor.authorPoso, A
dc.contributor.authorRakitin, OA
dc.contributor.authorHofmann-Lehmann, R
dc.date.accessioned2019-07-04T12:25:47Z
dc.date.available2019-07-04T12:25:47Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7665
dc.description.abstractWe report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesBioorganic and medicinal chemistry letters
dc.relation.urihttp://dx.doi.org/10.1016/j.bmcl.2019.05.016
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectfeline immunodeficiency virus (FIV)
dc.subjecthuman immunodeficiency virus (HIV)
dc.subjectselenium
dc.subjectzinc ejection
dc.subjectnucleocapsid protein
dc.titleSynthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Biomedicine
uef.solecris.id62536475en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier Ltd
dc.relation.doi10.1016/j.bmcl.2019.05.016
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1765-1768
dc.relation.issn0960-894X
dc.relation.issue14
dc.relation.volume29
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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