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dc.contributor.authorSerri, Carla
dc.contributor.authorFrigione, Mariaenrica
dc.contributor.authorRuponen, Marika
dc.contributor.authorUrtti, Arto
dc.contributor.authorBorzacchiello, Assunta
dc.contributor.authorBiondi, Marco
dc.contributor.authorMayol, Laura
dc.date.accessioned2019-08-21T09:58:04Z
dc.date.available2019-08-21T09:58:04Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7689
dc.description.abstractThe purpose of this study was to produce poly(DL-lactic-co-glycolic acid) (PLGA) – based microparticles (MPs), externally decorated with hyaluronic acid (HA). The MPs are intended for intravitreal injections in the treatment of posterior eye segment and have been designed to prolong the release of growth factors into the vitreous body, therefore aiming to increase the time interval between two consecutive injections. The MPs, prepared by a modified double emulsion-solvent evaporation technique and loaded with bovine serum albumins (BSA) and ciliary neurotrophic factor (CNTF), were spherical, with a diameter around 70 μm and a >90% encapsulation efficiency. Energy Dispersive Spectroscopy (EDS) outcomes indicated that HA presence in the external aqueous phase of the emulsion did affect the surface properties of MPs. Moreover, poloxamers drastically slowed down MP degradation properties which are, in turn, closely related to their ability to prolong drug release. This is promising for the envisaged application of the produced MPs. Further work will be devoted to optimizing MP formulation with respect to the envisaged intravitreal route of administration.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesColloids and surfaces b: biointerfaces
dc.relation.urihttp://dx.doi.org/10.1016/j.colsurfb.2019.06.044
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjecthyaluronic acid
dc.subjectmicroparticle
dc.subjectPLGA
dc.subjectpoloxamer
dc.subjectdiffusion
dc.subjectocular delivery
dc.titleElectron dispersive X-ray spectroscopy and degradation properties of hyaluronic acid decorated microparticles
dc.description.versionfinal draft
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id63330178en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier B.V.
dc.relation.doi10.1016/j.colsurfb.2019.06.044
dc.description.reviewstatuspeerReviewed
dc.format.pagerange896-901
dc.publisher.countryAlankomaat
dc.relation.issn0927-7765
dc.relation.volume181
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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