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dc.contributor.authorBolcos, PO
dc.contributor.authorMononen, ME
dc.contributor.authorTanaka, MS
dc.contributor.authorYang, M
dc.contributor.authorSuomalainen, JS
dc.contributor.authorNissi, MJ
dc.contributor.authorTöyräs, J
dc.contributor.authorMa, B
dc.contributor.authorLi, X
dc.contributor.authorKorhonen, RK
dc.date.accessioned2019-09-19T10:47:47Z
dc.date.available2019-09-19T10:47:47Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7768
dc.description.abstractBackground Finite element modelling can be used to evaluate altered loading conditions and failure locations in knee joint tissues. One limitation of this modelling approach has been experimental comparison. The aims of this proof-of-concept study were: 1) identify areas susceptible to osteoarthritis progression in anterior cruciate ligament reconstructed patients using finite element modelling; 2) compare the identified areas against changes in T2 and T1ρ values between 1-year and 3-year follow-up timepoints. Methods Two patient-specific finite element models of knee joints with anterior cruciate ligament reconstruction were created. The knee geometry was based on clinical magnetic resonance imaging and joint loading was obtained via motion capture. We evaluated biomechanical parameters linked with cartilage degeneration and compared the identified risk areas against T2 and T1ρ maps. Findings The risk areas identified by the finite element models matched the follow-up magnetic resonance imaging findings. For Patient 1, excessive values of maximum principal stresses and shear strains were observed in the posterior side of the lateral tibial and femoral cartilage. For Patient 2, high values of maximum principal stresses and shear strains of cartilage were observed in the posterior side of the medial joint compartment. For both patients, increased T2 and T1ρ values between the follow-up times were observed in the same areas. Interpretation Finite element models with patient-specific geometries and motions and relatively simple material models of tissues were able to identify areas susceptible to post-traumatic knee osteoarthritis. We suggest that the methodology presented here may be applied in large cohort studies.en
dc.language.isoenen
dc.publisherElsevier Ltden
dc.relation.ispartofseriesClinical biomechanicsen
dc.relation.urihttps://doi.org/10.1016/j.clinbiomech.2019.08.004en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectfinite-element analysisen
dc.subjectknee jointen
dc.subjectarticular cartilageen
dc.subjectgaiten
dc.subjectmagnetic resonance imagingen
dc.titleIdentification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1p and T2 imagingen
dc.description.versionfinal draften
dc.contributor.departmentDepartment of Applied Physics, activitiesen
uef.solecris.id64740611en
dc.type.publicationarticleen
dc.rights.accessrights© Authorsen
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020-EU.1.1./755037/EU/Novel algorithm for treatment planning of patients with osteoarthritis/ALGOAen
dc.relation.doi10.1016/j.clinbiomech.2019.08.004en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber104844
dc.relation.issn0268-0033en
dc.relation.volume78en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen


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