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dc.contributor.authorKamakura, R
dc.contributor.authorKovalainen, M
dc.contributor.authorRiikonen, J
dc.contributor.authorNissinen, T
dc.contributor.authorShere Raza, G
dc.contributor.authorWalkowiak, J
dc.contributor.authorLehto, VP
dc.contributor.authorHerzig, KH
dc.date.accessioned2019-11-04T12:59:00Z
dc.date.available2019-11-04T12:59:00Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7822
dc.description.abstractNovel treatment methods for obesity are urgently needed due to the increasing global severity of the problem. Gastrointestinal hormones, such as GLP-1 and PYY, are secreted by the enteroendocrine cells, playing a critical role in regulating food intake. Digested nutrients trigger the secretion of these hormones, which have a very short half-life. α-Linolenic acid (αLA) has been shown to stimulate GLP-1 secretion, however, chemical instability and fast uptake in the small intestine hinder its use in body weight management. We developed a novel delivery system based on inorganic mesoporous particles for αLA to increase secretion of gastrointestinal peptides. αLA was loaded to thermally hydrocarbonized porous silicon particles (THCPSi). 47.9 ± 3.84% and 30.7 ± 2.86% of αLA was released during 6 h from 3.0% and 9.2% loading degree (w/w) samples in vitro, respectively. Native αLA (50 µM) significantly increased GLP-1 secretion from enteroendocrine STC-1 and GLUTag cell lines. αLA loaded THCPSi significantly and dose dependently stimulated GLP-1 secretion from STC-1 cells, whereas empty particles did not. We demonstrated in vitro that THCPSi particles have the potential to be used as a controlled delivery system for nutrients such as αLA, increasing GLP-1 secretion. Our results justify further in vivo investigations.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesEuropean journal of pharmaceutics and biopharmaceutics
dc.relation.urihttp://dx.doi.org/10.1016/j.ejpb.2019.09.009
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectcontrolled delivery
dc.subjectα-linolenic acid
dc.subjectnutrients
dc.subjectporous silicon
dc.subjectGLP-1
dc.subjectenteroendocrine cells
dc.subjectfood intake
dc.titleInorganic mesoporous particles for controlled [alpha]-linolenic acid delivery to stimulate GLP-1 secretion in vitro
dc.description.versionfinal draft
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id65177121en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Elsevier B.V.
dc.relation.doi10.1016/j.ejpb.2019.09.009
dc.description.reviewstatuspeerReviewed
dc.format.pagerange132-138
dc.publisher.countrySaksa
dc.relation.issn0939-6411
dc.relation.volume144
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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