Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß
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CitationGureviciene Irina. Gurevicius Kestutis. Mugantseva Ekaterina. Kislin Mikhail. Khiroug Leonard. Tanila Heikki. (2017). Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß. Journal of Alzheimer's Disease, 55 (1) , 147-157. 10.3233/JAD-160453.
Amyloid plaques, although inducing damage to the immediately surrounding neuropil, have been proposed to provide a relatively innocuous way to deposit toxic soluble amyloid-β (Aβ) species. Here we address this hypothesis by exploring spread and absorption of fluorescent Aβ to pre-existing amyloid plaques after local application in wild-type mice versus APP/PS1 transgenic mice with amyloid plaques. Local intracortical or intracerebroventricular injection of fluorescently-labeled Aβ in APP/PS1 mice with a high plaque density resulted in preferential accumulation of the peptide in amyloid plaques in both conventional postmortem histology and in live imaging using two-photon microscopy. These findings support the contention that amyloid plaques may act as buffers to protect neurons from the toxic effects of momentary high concentrations of soluble Aβ oligomers.
Subjectsalzheimer’s disease amyloid-β in vivo imaging multiphoton transgenic
Link to the original itemhttp://dx.doi.org/10.3233/JAD-160453
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