Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß
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CitationGureviciene Irina. Gurevicius Kestutis. Mugantseva Ekaterina. Kislin Mikhail. Khiroug Leonard. Tanila Heikki. (2017). Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß. Journal of Alzheimer's Disease, 55 (1) , 147-157. 10.3233/JAD-160453.
Amyloid plaques, although inducing damage to the immediately surrounding neuropil, have been proposed to provide a relatively innocuous way to deposit toxic soluble amyloid-β (Aβ) species. Here we address this hypothesis by exploring spread and absorption of fluorescent Aβ to pre-existing amyloid plaques after local application in wild-type mice versus APP/PS1 transgenic mice with amyloid plaques. Local intracortical or intracerebroventricular injection of fluorescently-labeled Aβ in APP/PS1 mice with a high plaque density resulted in preferential accumulation of the peptide in amyloid plaques in both conventional postmortem histology and in live imaging using two-photon microscopy. These findings support the contention that amyloid plaques may act as buffers to protect neurons from the toxic effects of momentary high concentrations of soluble Aβ oligomers.