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The association between frontotemporal lobar degeneration and bullous pemphigoid

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Date
2018
Author(s)
Katisko, Kasper
Kokkonen, Nina
Krüger, Johanna
Hartikainen, Päivi
Koivisto, Anne
Helisalmi, Seppo
Korhonen, Ville
Kokki, Merja
Tuusa, Jussi
Herukka, Sanna-Kaisa
Solje, Eino
Haapasalo, Annakaisa
Tasanen, Kaisa
Remes, Anne
Unique identifier
10.3233/JAD-180624
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Citation
Katisko, Kasper. Kokkonen, Nina. Krüger, Johanna. Hartikainen, Päivi. Koivisto, Anne. Helisalmi, Seppo. Korhonen, Ville. Kokki, Merja. Tuusa, Jussi. Herukka, Sanna-Kaisa. Solje, Eino. Haapasalo, Annakaisa. Tasanen, Kaisa. Remes, Anne. (2018). The association between frontotemporal lobar degeneration and bullous pemphigoid.  Journal of Alzheimer's Disease, 66 (2) , 743-750. 10.3233/JAD-180624.
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Abstract

Recent studies have shown an epidemiological and immunological association between bullous pemphigoid (BP) and several neurological or psychiatric diseases. Here, our aim was for the first time to specify whether an association exists between BP and frontotemporal lobar degeneration (FTLD). Medical histories of FTLD patients (N = 196) were screened for clinical comorbidity, and BP180 and BP230 autoantibodies were analyzed in the sera of FTLD patients (N = 70, including 24 C9orf72 repeat expansion carriers) by BP180-NC16A-ELISA and BP230-ELISA. One FTLD patient (C9orf72 repeat expansion carrier) had a comorbid diagnosis of BP. Increased levels of serum BP180 autoantibodies (cutoff value >9 U/ml) were detected more often in FTLD patients (10.0%) than in controls (4.9%). Moreover, elevated levels of both BP180 and BP230 autoantibodies were found more often in C9orf72 repeat expansion-carrying FTLD than non-carrying patients or controls. However, none of these differences reached a statistical significance likely due to our limited cohort size. In conclusion, our findings suggest that subset of FTLD patients especially with the C9orf72 repeat expansion may have an immunological association with BP.

Subjects
autoantibody   bullous pemphigoid   C9orf72   comorbidity   dementia   frontotemporal dementia   immunology   
URI
https://erepo.uef.fi/handle/123456789/7917
Link to the original item
http://dx.doi.org/10.3233/JAD-180624
Publisher
IOS Press
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  • Terveystieteiden tiedekunta [1330]
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