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Maternal use of drugs and preeclampsia

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final draft
Date
2019
Author(s)
Sahlman, H
Koponen, M
El-Nezami, H
Vahakangas, K
Keski-Nisula, L
Unique identifier
10.1111/bcp.14117
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Self-archived article

Citation
Sahlman, H. Koponen, M. El-Nezami, H. Vahakangas, K. Keski-Nisula, L. (2019). Maternal use of drugs and preeclampsia.  British journal of clinical pharmacology, 85 (12) , 2848-2855. 10.1111/bcp.14117.
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© The British Pharmacological Society
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Abstract

Aims
The aim was to compare and describe maternal use of drugs between women with preeclampsia and controls and to estimate the possible association with preeclampsia.

Methods
The study cohort was collected from the Kuopio University Hospital Birth Register, which includes information about all women who gave birth in Kuopio University Hospital during the years 2002–2016, including information from approximately 36 000 parturients, of whom 1252 had preeclampsia. Maternal use of 16 groups of drugs during pregnancy was analysed from all women with preeclampsia and 1256 controls.

Results
Every second woman had used at least 1 drug during pregnancy but those with preeclampsia had used significantly more than the controls (cases 59.5% vs controls 35.5%; p < 0.001). In both study groups, the most commonly used drugs were antibiotics (cases 19.5%, controls 17.0%), antihypertensives (cases 29.0%, controls 7.6%) and paracetamol (cases 13.1%, controls 5.9%). Women with preeclampsia had used significantly more benzodiazepines, paracetamol, antihypertensives and acid‐suppressive drugs than the women in the control group (p < 0.05).

Conclusions
Women with preeclampsia were more likely to use medicines during pregnancy. While the association between benzodiazepines, antihypertensives and acid‐suppressive drugs and preeclampsia may be explained by reverse causation, the association of paracetamol with preeclampsia remains to be clarified. Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.

Subjects
maternal use of drugs   preeclampsia   pregnancy   
URI
https://erepo.uef.fi/handle/123456789/7954
Link to the original item
http://dx.doi.org/10.1111/bcp.14117
Publisher
Wiley
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  • Terveystieteiden tiedekunta [1324]
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