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dc.contributor.authorSahlman, H
dc.contributor.authorKoponen, M
dc.contributor.authorEl-Nezami, H
dc.contributor.authorVahakangas, K
dc.contributor.authorKeski-Nisula, L
dc.date.accessioned2020-01-21T09:22:56Z
dc.date.available2020-01-21T09:22:56Z
dc.date.issued2019
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7954
dc.description.abstractAims The aim was to compare and describe maternal use of drugs between women with preeclampsia and controls and to estimate the possible association with preeclampsia. Methods The study cohort was collected from the Kuopio University Hospital Birth Register, which includes information about all women who gave birth in Kuopio University Hospital during the years 2002–2016, including information from approximately 36 000 parturients, of whom 1252 had preeclampsia. Maternal use of 16 groups of drugs during pregnancy was analysed from all women with preeclampsia and 1256 controls. Results Every second woman had used at least 1 drug during pregnancy but those with preeclampsia had used significantly more than the controls (cases 59.5% vs controls 35.5%; p < 0.001). In both study groups, the most commonly used drugs were antibiotics (cases 19.5%, controls 17.0%), antihypertensives (cases 29.0%, controls 7.6%) and paracetamol (cases 13.1%, controls 5.9%). Women with preeclampsia had used significantly more benzodiazepines, paracetamol, antihypertensives and acid‐suppressive drugs than the women in the control group (p < 0.05). Conclusions Women with preeclampsia were more likely to use medicines during pregnancy. While the association between benzodiazepines, antihypertensives and acid‐suppressive drugs and preeclampsia may be explained by reverse causation, the association of paracetamol with preeclampsia remains to be clarified. Because paracetamol is a frequently used drug, more information about its safety during pregnancy including its role in preeclampsia is urgently needed.
dc.language.isoenglanti
dc.publisherWiley
dc.relation.ispartofseriesBritish journal of clinical pharmacology
dc.relation.urihttp://dx.doi.org/10.1111/bcp.14117
dc.rightsAll rights reserved
dc.subjectmaternal use of drugs
dc.subjectpreeclampsia
dc.subjectpregnancy
dc.titleMaternal use of drugs and preeclampsia
dc.description.versionfinal draft
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentSchool of Medicine / Clinical Nutrition,School of Medicine / Clinical Medicine
uef.solecris.id66392783en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© The British Pharmacological Society
dc.relation.doi10.1111/bcp.14117
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2848-2855
dc.relation.issn0306-5251
dc.relation.issue12
dc.relation.volume85
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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