Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
Tiedosto(t)
Rinnakkaistallenteen versio
final draftPäivämäärä
2020Tekijä(t)
Yksilöllinen tunniste
10.1249/MSS.0000000000002216Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Haapala, EA. Wiklund, P. Lintu, N. Tompuri, T. Väistö, J. Finni, T. Tarkka, IM. Kemppainen. T. Barker, AR. Ekelund, U. Brage, S. Lakka, TA. (2020). Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children. Medicine and science in sports and exercise, 52 (5) , 1144-1152. 10.1249/MSS.0000000000002216.Oikeudet
Tiivistelmä
Purpose
Few studies have investigated the independent and joint associations of cardiorespiratory fitness (CRF) and body fat percentage (BF%) with insulin resistance in children. We investigated the independent and combined associations of CRF and BF% with fasting glycaemia and insulin resistance and their interactions with physical activity (PA) and sedentary time among 452 children aged 6–8 years.
Methods
We assessed CRF with a maximal cycle ergometer exercise test and used allometrically scaled maximal power output (Wmax) for lean body mass (LM1.13) and body mass (BM1) as measures of CRF. BF% and LM were measured by dual-energy X-ray absorptiometry, fasting glycaemia by fasting plasma glucose, and insulin resistance by fasting serum insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). PA energy expenditure (PAEE), moderate-to-vigorous PA (MVPA), and sedentary time were assessed by combined movement and heart rate sensor.
Results
Wmax/LM1.13 was not associated with glucose (β=0.065, 95% CI=-0.031 to 0.161), insulin (β=-0.079, 95% CI=-0.172 to 0.015), or HOMA-IR (β=-0.065, 95% CI=-0.161 to 0.030). Wmax/BM1 was inversely associated with insulin (β=-0.289, 95% CI=-0.377 to -0.200) and HOMA-IR (β=-0.269, 95% CI=-0.359 to -0.180). BF% was directly associated with insulin (β=0.409, 95% CI=0.325 to 0.494) and HOMA-IR (β=0.390, 95% CI=0.304 to 0.475). Higher Wmax/BM1, but not Wmax/LM1.13, was associated with lower insulin and HOMA-IR in children with higher BF%. Children with higher BF% and who had lower levels of MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR.
Conclusion
Children with higher BF% together with less MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. CRF appropriately controlled for body size and composition using LM was not related to insulin resistance among children.
Avainsanat
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1249/MSS.0000000000002216Julkaisija
Ovid Technologies (Wolters Kluwer Health)Kokoelmat
- Terveystieteiden tiedekunta [1735]