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dc.contributor.authorHaapala, EA
dc.contributor.authorWiklund, P
dc.contributor.authorLintu, N
dc.contributor.authorTompuri, T
dc.contributor.authorVäistö, J
dc.contributor.authorFinni, T
dc.contributor.authorTarkka, IM
dc.contributor.authorKemppainen. T
dc.contributor.authorBarker, AR
dc.contributor.authorEkelund, U
dc.contributor.authorBrage, S
dc.contributor.authorLakka, TA
dc.date.accessioned2020-01-21T09:58:28Z
dc.date.available2020-01-21T09:58:28Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/7956
dc.description.abstractPurpose Few studies have investigated the independent and joint associations of cardiorespiratory fitness (CRF) and body fat percentage (BF%) with insulin resistance in children. We investigated the independent and combined associations of CRF and BF% with fasting glycaemia and insulin resistance and their interactions with physical activity (PA) and sedentary time among 452 children aged 6–8 years. Methods We assessed CRF with a maximal cycle ergometer exercise test and used allometrically scaled maximal power output (Wmax) for lean body mass (LM1.13) and body mass (BM1) as measures of CRF. BF% and LM were measured by dual-energy X-ray absorptiometry, fasting glycaemia by fasting plasma glucose, and insulin resistance by fasting serum insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). PA energy expenditure (PAEE), moderate-to-vigorous PA (MVPA), and sedentary time were assessed by combined movement and heart rate sensor. Results Wmax/LM1.13 was not associated with glucose (β=0.065, 95% CI=-0.031 to 0.161), insulin (β=-0.079, 95% CI=-0.172 to 0.015), or HOMA-IR (β=-0.065, 95% CI=-0.161 to 0.030). Wmax/BM1 was inversely associated with insulin (β=-0.289, 95% CI=-0.377 to -0.200) and HOMA-IR (β=-0.269, 95% CI=-0.359 to -0.180). BF% was directly associated with insulin (β=0.409, 95% CI=0.325 to 0.494) and HOMA-IR (β=0.390, 95% CI=0.304 to 0.475). Higher Wmax/BM1, but not Wmax/LM1.13, was associated with lower insulin and HOMA-IR in children with higher BF%. Children with higher BF% and who had lower levels of MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. Conclusion Children with higher BF% together with less MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. CRF appropriately controlled for body size and composition using LM was not related to insulin resistance among children.
dc.language.isoenglanti
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofseriesMedicine and science in sports and exercise
dc.relation.urihttp://dx.doi.org/10.1249/MSS.0000000000002216
dc.rightsAll rights reserved
dc.subjectdiabetes
dc.subjectyouth
dc.subjectexercise
dc.subjectperformance
dc.subjectinsulin
dc.subjectinsulin sensitivity
dc.subjectobesity
dc.titleCardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Biomedicine
uef.solecris.id66797791en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© American College of Sports Medicine
dc.relation.doi10.1249/MSS.0000000000002216
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1144-1152
dc.relation.issn0195-9131
dc.relation.issue5
dc.relation.volume52
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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