dc.contributor.author | Ulven, SM | |
dc.contributor.author | Holven, KB | |
dc.contributor.author | Rundblad, A | |
dc.contributor.author | Myhrstad, MCW | |
dc.contributor.author | Leder, L | |
dc.contributor.author | Dahlman, I | |
dc.contributor.author | Mello, VD | |
dc.contributor.author | Schwab, U | |
dc.contributor.author | Carlberg, C | |
dc.contributor.author | Pihlajamäki, J | |
dc.contributor.author | Hermansen, K | |
dc.contributor.author | Dragsted, LO | |
dc.contributor.author | Gunnarsdottir, I | |
dc.contributor.author | Cloetens, L | |
dc.contributor.author | Åkesson, B | |
dc.contributor.author | Rosqvist, F | |
dc.contributor.author | Hukkanen, J | |
dc.contributor.author | Herzig, KH | |
dc.contributor.author | Savolainen, MJ | |
dc.contributor.author | Risérus, U | |
dc.contributor.author | et al. incl. Uusitupa, M | |
dc.date.accessioned | 2020-01-24T13:35:38Z | |
dc.date.available | 2020-01-24T13:35:38Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/7980 | |
dc.description.abstract | A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function. | |
dc.language.iso | englanti | |
dc.publisher | MDPI AG | |
dc.relation.ispartofseries | Nutrients | |
dc.relation.uri | http://dx.doi.org/10.3390/nu11122932 | |
dc.rights | CC BY 4.0 | |
dc.subject | metabolic syndrome | |
dc.subject | randomized controlled dietary intervention | |
dc.subject | gene expression | |
dc.subject | peripheral blood mononuclear cells | |
dc.subject | inflammation | |
dc.title | An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study | |
dc.description.version | published version | |
dc.contributor.department | School of Medicine / Clinical Nutrition | |
dc.contributor.department | Faculty of Health Sciences, shared activities,School of Medicine / Biomedicine | |
uef.solecris.id | 67110498 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.relation.doi | 10.3390/nu11122932 | |
dc.description.reviewstatus | peerReviewed | |
dc.publisher.country | Sveitsi | |
dc.relation.articlenumber | 2932 | |
dc.relation.issue | 12 | |
dc.relation.volume | 11 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Open access -julkaisukanavassa ilmestynyt julkaisu | |
dc.rights.copyright | © Authors | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |