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dc.contributor.authorHeinjoki, M
dc.contributor.authorKarjalainen, M
dc.contributor.authorSaltevo, J
dc.contributor.authorTiihonen, M
dc.contributor.authorHaanpää, M
dc.contributor.authorKautiainen, H
dc.contributor.authorMäntyselkä, P
dc.date.accessioned2020-03-06T13:12:34Z
dc.date.available2020-03-06T13:12:34Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8043
dc.description.abstractBackground Due to these changes in kidney function, aging kidneys are more prone to drug-induced impairments in renal properties. Diabetes has been associated with the declined kidney function and an elevated risk of renal failure. The aim of this study is to compare kidney function and potentially nephrotoxic drug use among home-dwelling older persons with or without diabetes. Methods A total of 259 persons with and 259 persons without diabetes and aged ≥65 years were randomly selected to participate in a health examination with complete data gathered from 363 individuals (187 with diabetes and 176 without diabetes). The estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Each participant was categorized based on the nephrotoxic profile of their medications. Results There were no differences in mean eGFR values (77.5 ± 18.8 vs. 80.5 ± 14.8 ml/min/1.73m2, p = 0.089) or in the proportion of participants with eGFR < 60 ml/min/1.73m2 among persons with diabetes (16% vs. 10%, p = 0.070), compared to persons without diabetes. Potentially nephrotoxic drug use was similar between the groups. The mean number of potentially nephrotoxic drugs was 1.06 ± 0.88 in those with and 0.97 ± 1.05 in those without diabetes (p = 0.39). Conclusions The kidney function of older persons with diabetes does not differ from that of older persons without diabetes and furthermore potentially nephrotoxic drug use seem to play only a minor role in the decline in kidney function among home-dwelling persons in the Inner-Savo district.
dc.language.isoenglanti
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofseriesBmc nephrology
dc.relation.urihttp://dx.doi.org/10.1186/s12882-020-1684-4
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleKidney function and nephrotoxic drug use among older home-dwelling persons with or without diabetes in Finland
dc.description.versionpublished version
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentSchool of Medicine / Public Health
uef.solecris.id67845217en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1186/s12882-020-1684-4
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber11
dc.relation.volume21
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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