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dc.contributor.authorNoerman, S
dc.contributor.authorKlåvus, A
dc.contributor.authorJärvelä-Reijonen, E
dc.contributor.authorKarhunen, L
dc.contributor.authorAuriola, S
dc.contributor.authorKorpela, R
dc.contributor.authorLappalainen, R
dc.contributor.authorKujala, UM
dc.contributor.authorPuttonen, S
dc.contributor.authorKolehmainen, M
dc.contributor.authorHanhineva, K
dc.date.accessioned2020-03-11T09:09:10Z
dc.date.available2020-03-11T09:09:10Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8057
dc.description.abstractPsychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement of psychological well-being using non-targeted liquid chromatography-mass spectrometry (LC-MS) platform. The metabolic profiles of volunteers participating in the face-to-face intervention group (n = 60) in a randomised lifestyle intervention were compared to ones of controls (n = 64) between baseline and 36-week follow-up. Despite modest differences in metabolic profile between groups, we found associations between phosphatidylcholines (PCs) and several parameters indicating stress, adiposity, relaxation, and recovery. The relief of heart-rate-variability-based stress had positive, while improved indices of recovery and relaxation in the intervention group had an inverse association with the reduction of e.g. lysophosphatidylcholines (LPC). Interleukin-1 receptor antagonist and adiposity correlated positively with the suppressed PCs and negatively with the elevated plasmalogens PC(P-18:0/22:6) and PC(P-18:0/20:4). Also, we found changes in an unknown class of lipids over time regardless of the intervention groups, which also correlated with physiological and psychological markers of stress. The associations between lipid changes with some markers of psychological wellbeing and body composition may suggest the involvement of these lipids in the shared mechanisms between psychological and metabolic health.
dc.language.isoenglanti
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofseriesScientific reports
dc.relation.urihttp://dx.doi.org/10.1038/s41598-020-59051-x
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titlePlasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Clinical Nutrition
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id68530845en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© Authors
dc.relation.doi10.1038/s41598-020-59051-x
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber2143
dc.relation.issue1
dc.relation.volume10
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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