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Automatic assessment of the myoclonus severity from videos recorded according to standardized Unified Myoclonus Rating Scale protocol and using human pose and body movement analysis

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Date
2020
Author(s)
Hyppönen, J
Hakala, A
Annala, K
Zhang, H
Peltola, J
Mervaala, E
Kälviäinen, R
Unique identifier
10.1016/j.seizure.2020.01.014
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Citation
Hyppönen, J. Hakala, A. Annala, K. Zhang, H. Peltola, J. Mervaala, E. Kälviäinen, R. (2020). Automatic assessment of the myoclonus severity from videos recorded according to standardized Unified Myoclonus Rating Scale protocol and using human pose and body movement analysis.  Seizure: european journal of epilepsy, 76, 72-78. 10.1016/j.seizure.2020.01.014.
Rights
© British Epilepsy Association
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CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Purpose
Myoclonus in progressive myoclonus epilepsy type 1 (EPM1) patients shows marked variability, which presents a substantial challenge in devising treatment and conducting clinical trials. Consequently, fast and objective myoclonus quantification methods are needed.

Methods
Ten video-recorded unified myoclonus rating scale (UMRS) myoclonus with action tests were performed on EPM1 patients who were selected for the development and testing of the automatic myoclonus quantification method. Human pose and body movement analyses of the videos were used to identify body keypoints and further analyze movement smoothness and speed. The automatic myoclonus rating scale (ARMS) was developed. It included the jerk count during movement score and the log dimensionless jerk (LDLJ) score to evaluate changes in the smoothness of movement.

Results
The scores obtained with the automatic analyses showed moderate to strong significant correlation with the UMRS myoclonus with action scores. The jerk count of the primary keypoints and the LDLJ scores were effective in the evaluation of the myoclonic jerks during hand movements. They also correlated moderately to strongly with the total UMRS test panel scores (r2 = 0,77, P = 0,009 for the jerk count score and r2 = 0,88, P = 0,001 for the LDLJ score). The automatic analyses was weaker in quantification of the neck, trunk, and leg myoclonus.

Conclusion
Automatic quantification of myoclonic jerks using human pose and body movement analysis of patients’ videos is feasible and was found to be quite consistent with the accepted clinical gold standard quantification method. Based on the results of this study, the automatic analytical method should be further developed and validated to improve myoclonus severity follow-up for EPM1 patients.

Subjects
EPM1   myoclonus   unified myoclonus rating scale   pose estimation analysis   
URI
https://erepo.uef.fi/handle/123456789/8076
Link to the original item
http://dx.doi.org/10.1016/j.seizure.2020.01.014
Publisher
Elsevier BV
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  • Terveystieteiden tiedekunta [1337]
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