Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The EDCMET project: Metabolic effects of endocrine disruptors

Thumbnail
Files
Article (697.4Kb)
Self archived version
published version
Date
2020
Author(s)
Küblbeck, Jenni
Vuorio, Taina
Niskanen, Jonna
Fortino, Vittorio
Braeunin, Albert
Abass, Khaled
Rautio, Arja
Hakkola, Jukka
Honkakoski, Paavo
Levonen, Anna-Liisa
Unique identifier
10.3390/ijms21083021
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Küblbeck, Jenni. Vuorio, Taina. Niskanen, Jonna. Fortino, Vittorio. Braeunin, Albert. Abass, Khaled. Rautio, Arja. Hakkola, Jukka. Honkakoski, Paavo. Levonen, Anna-Liisa. (2020). The EDCMET project: Metabolic effects of endocrine disruptors.  International journal of molecular sciences, 21 (8) , 3021. 10.3390/ijms21083021.
Rights
© the authors
Licensed under
CC BY http://creativecommons.org/licenses/by/4.0/
Abstract

Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with
hormones in the body’s endocrine systems and have been associated with a diverse array of health
issues. The concept of endocrine disruption has recently been extended to metabolic alterations
that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an
increasing health concern worldwide. However, while epidemiological and experimental data
on the close association of EDs and adverse metabolic e ects are mounting, predictive methods
and models to evaluate the detailed mechanisms and pathways behind these observed e ects are
lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic e ects of
Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project
brings together systems toxicologists; experimental biologists with a thorough understanding of the
molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological
skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes.
During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate
(pre)validated test methods to assess the metabolic e ects of Eds, and to predict emergent adverse
biological phenotypes by following the adverse outcome pathway (AOP) paradigm.

Subjects
endocrine disruptors (EDs)   nuclear receptors (NRs)   metabolism   metabolic syndrome   obesity   risk assessment   human health   adverse outcome pathway (AOP)   assay validation   
URI
https://erepo.uef.fi/handle/123456789/8116
Link to the original item
http://dx.doi.org/10.3390/ijms21083021
Publisher
MDPI AG
Collections
  • Terveystieteiden tiedekunta [1335]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap