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dc.contributor.authorTenhunen, Jonna
dc.contributor.authorKokkola, Tarja
dc.contributor.authorHuovinen, Marjo
dc.contributor.authorRahnasto-Rilla, Minna
dc.contributor.authorLahtela-Kakkonen, Maija
dc.date.accessioned2020-05-22T12:01:47Z
dc.date.available2020-05-22T12:01:47Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8137
dc.description.abstractThe epigenetic regulation of gene expression is controlled by various processes, of which one is histone acetylation. Many proteins control gene expression via histone acetylation. Those proteins include sirtuins (SIRTs) and bromodomain and extraterminal proteins (BETs), which are known to regulate same cellular processes and pathways. The aim of this study was to explore BET inhibitors’ effects on SIRT1. Previously we showed that BET inhibitor (+)-JQ1 increases SIRT1 levels, but in the current study we used also other, structurally diverse BET inhibitors, I-BET151 and Pfi-1, and examined their effects on SIRT1 levels in two breast cancer cell lines. The results differed between the inhibitors and also between the cell lines. (+)-JQ1 had opposite effects on SIRT1 levels in the two cell lines, I-BET151 increased the levels in both cell lines, and Pfi-1 had no effect. In conclusion, the effect of structurally diverse BET inhibitors on SIRT1 levels is divergent, and the responses might also be cell type-dependent. These findings are important for all SIRT1 and BET inhibitor-related research, and they show that different BET inhibitors might have important individual effects.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesGene
dc.relation.urihttp://dx.doi.org/10.1016/j.gene.2020.144558
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectepigenetic regulation
dc.subjectSIRT1
dc.subjectBET inhibitor
dc.titleImpact of Structurally Diverse BET Inhibitors on SIRT1
dc.description.versionfinal draft
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id69265737en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2020 Elsevier B.V.
dc.relation.doi10.1016/j.gene.2020.144558
dc.description.reviewstatuspeerReviewed
dc.format.pagerange144558
dc.publisher.countryAlankomaat
dc.relation.issn0378-1119
dc.relation.volume741
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessEi


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