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dc.contributor.authorTanska, P
dc.contributor.authorVenäläinen, MS
dc.contributor.authorErdemir, A
dc.contributor.authorKorhonen, RK
dc.date.accessioned2020-06-04T08:21:46Z
dc.date.available2020-06-04T08:21:46Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8147
dc.description.abstractCharacterization of the mechanical environment of cells in collagenous biological tissues during different daily activities is crucial for understanding the role of mechanics on cell biosynthesis and tissue health. However, current imaging methods are limited in characterizing very fast deformations of cells. This could be achieved with computational multiscale modeling, but current models accommodating collagen fibril networks and poroelastic ground matrix have included only a single cell. In this study, a workflow was developed for generating a three-dimensional multiscale model with imaging-based anatomical cell distributions and their micro-environment (pericellular and extracellular matrix). Fibril-reinforced poroelastic material models with (FRPES) and without (FRPE) swelling were implemented into the model and simulations were performed for evaluating cell deformations before and after experimental loading conducted for rabbit knee joint cartilage. We observed that the cells experienced considerably different deformation based on their location in all models. Both FRPE and FRPES models were able to predict the trends in the changes in cell deformations, although the average and median magnitudes differed between the model predictions and experiments. However, the FRPES model results were generally closer to the experimental results. Current findings suggest that morphological properties of cells are affected by the variations in the tissue properties between the samples and variations within the sample caused by the measurement geometry, local structure and composition. Thus, it would be important to consider the anatomical distribution and location of multiple cells along with the structure of fibril networks if cell deformation metrics are evaluated in collagenous tissues.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesJournal of biomechanics
dc.relation.urihttp://dx.doi.org/10.1016/j.jbiomech.2020.109648
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectarticular cartilage
dc.subjectfinite element analysis
dc.subjectcollagen
dc.subjectchondrocyte
dc.subjectporoelastic
dc.subjectfibril-reinforced
dc.subjectcell mechanics
dc.titleA multiscale framework for evaluating three-dimensional cell mechanics in fibril-reinforced poroelastic tissues with anatomical cell distribution - Analysis of chondrocyte deformation behavior in mechanically loaded articular cartilage
dc.description.versionfinal draft
dc.contributor.departmentDepartment of Applied Physics, activities
uef.solecris.id68436263en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2020 The Author(s)
dc.relation.doi10.1016/j.jbiomech.2020.109648
dc.description.reviewstatuspeerReviewed
dc.format.pagerange109648
dc.relation.issn0021-9290
dc.relation.volume101
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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