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dc.contributor.authorKanninen, KM
dc.contributor.authorLampinen, R
dc.contributor.authorRantanen, LM
dc.contributor.authorOdendaal, L
dc.contributor.authorJalava, P
dc.contributor.authorChew, S
dc.contributor.authorWhite, AR
dc.date.accessioned2020-06-05T12:05:16Z
dc.date.available2020-06-05T12:05:16Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8157
dc.description.abstractAir pollution is a major, global public health concern. A growing body of evidence shows that exposure to air pollutants may impair the brain. Living in highly polluted areas has been linked to several neurodegenerative diseases, where exposure to complex mixtures of air pollutants in urban environments may have harmful effects on brain function. These harmful effects are thought to originate from elevated inflammation and oxidative stress. The olfactory epithelium is a key entry site of air pollutants into the brain as the particles are deposited in the upper airways and the nasal region. A potential source of patient-derived cells for study of air pollutant effects is the olfactory mucosa, which constitutes a central part of the olfactory epithelium. This review first summarizes the current literature on the available in vitro models of the olfactory epithelium. It then describes how alterations of the olfactory mucosa are linked to neurodegeneration and discusses potential therapeutic applications of these cells for neurodegenerative diseases. Finally, it reviews the research performed on the effects of air pollutant exposure in cells of the olfactory epithelium. Patient-derived olfactory epithelial models hold great promise for not only elucidating the molecular and cellular pathophysiology of neurodegenerative disorders, but for providing key understanding about air pollutant particle entry and effects at this key brain entry site.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesNeurochemistry international
dc.relation.urihttp://dx.doi.org/10.1016/j.neuint.2020.104729
dc.rightsAll rights reserved
dc.subjectin vitro models
dc.subjectolfactory system
dc.subjectair pollution
dc.subjectparticulate matter
dc.subjectenvironmental health
dc.titleOlfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration
dc.description.versionfinal draft
dc.contributor.departmentA.I. Virtanen -instituutti
dc.contributor.departmentYmpäristö- ja biotieteiden laitos / Toiminta
uef.solecris.id69711908en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2020 Elsevier Ltd.
dc.relation.doi10.1016/j.neuint.2020.104729
dc.description.reviewstatuspeerReviewed
dc.publisher.countryAlankomaat
dc.relation.articlenumber104729
dc.relation.issn0197-0186
dc.relation.volume136
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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