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dc.contributor.authorRaha, Syamal
dc.contributor.authorMallick, Rahul
dc.contributor.authorBasak, Sanjay
dc.contributor.authorDuttaroy, Asim K
dc.date.accessioned2020-06-22T09:33:21Z
dc.date.available2020-06-22T09:33:21Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8199
dc.description.abstractCopper (Cu) is an essential micronutrient for both pathogens and the hosts during viral infection. Cu is involved in the functions of critical immune cells such as T helper cells, B cells, neutrophils natural killer (NK) cells, and macrophages. These blood cells are involved in the killing of infectious microbes, in cell-mediated immunity and the production of specific antibodies against the pathogens. Cu-deficient humans show an exceptional susceptibility to infections due to the decreased number and function of these blood cells. Besides, Cu can kill several infectious viruses such as bronchitis virus, poliovirus, human immunodeficiency virus type 1(HIV-1), other enveloped or nonenveloped, single- or double-stranded DNA and RNA viruses. Moreover, Cu has the potent capacity of contact killing of several viruses, including SARS‐CoV‐2. Since the current outbreak of the COVID-19 continues to develop, and there is no vaccine or drugs are currently available, the critical option is now to make the immune system competent to fight against the SARS‐CoV‐2. Based on available data, we hypothesize that enrichment of plasma copper levels will boost both the innate and adaptive immunity in people. Moreover, owing to its potent antiviral activities, Cu may also act as a preventive and therapeutic regime against COVID-19.
dc.language.isoenglanti
dc.publisherElsevier BV
dc.relation.ispartofseriesMedical hypotheses
dc.relation.urihttp://dx.doi.org/10.1016/j.mehy.2020.109814
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectcopper
dc.subjectcoronavirus
dc.subjectCOVID-19
dc.subjectSARS‐CoV‐2
dc.subjectcontact killing
dc.subjectcu-deficiency
dc.subjectROS
dc.subjectTh1/Th2 cells
dc.subjectCuONPs
dc.subjectblood cells
dc.subjectimmunity
dc.subjectcupric chloride
dc.subjectviral infection
dc.titleIs Copper beneficial for COVID-19 patients?
dc.description.versionpublished version
dc.contributor.departmentA.I. Virtanen -instituutti
uef.solecris.id70473483en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2020 The Authors
dc.relation.doi10.1016/j.mehy.2020.109814
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber109814
dc.relation.issn0306-9877
dc.relation.volume142
dc.rights.accesslevelopenAccess
dc.type.okmA1
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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