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Cough as an adverse effect on inhalation pharmaceutical products

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Item embargoed until 2021-07-15. Restrictions imposed by the publisher
Self archived version
final draft
Date
2020
Author(s)
Chang, RYK
Kwok, PCL
Ghassabian, S
Brannan, JD
Koskela, HO
Chan, H-K
Unique identifier
10.1111/bph.15197
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Self-archived article

Citation
Chang, RYK. Kwok, PCL. Ghassabian, S. Brannan, JD. Koskela, HO. Chan, H-K. (2020). Cough as an adverse effect on inhalation pharmaceutical products.  British journal of pharmacology, 177 (18) , 4096-4112. 10.1111/bph.15197.
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© 2020 The British Pharmacological Society
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Abstract

Cough is an adverse effect that may hinder the delivery of drugs into the lungs. Chemical or mechanical stimulants activate the transient receptor potential in some airway afferent nerves (C‐fibres or A‐fibres) to trigger cough. Types of inhaler device and drug, dose, excipients and formulation characteristics, including pH, tonicity, aerosol output and particle size may trigger cough by stimulating the cough receptors. Release of inflammatory mediators may increase the sensitivity of the cough receptors to stimulants. The cough‐provoking effect of aerosols is enhanced by bronchoconstriction in diseased airways and reduces drug deposition in the target pulmonary regions. In this article, we review the factors by which inhalation products may cause cough.

Subjects
adverse effect   aerosol   cough   inhalation   pharmaceutical products   
URI
https://erepo.uef.fi/handle/123456789/8281
Link to the original item
http://dx.doi.org/10.1111/bph.15197
Publisher
Wiley
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  • Terveystieteiden tiedekunta [1324]
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