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dc.contributor.authorChang, RYK
dc.contributor.authorKwok, PCL
dc.contributor.authorGhassabian, S
dc.contributor.authorBrannan, JD
dc.contributor.authorKoskela, HO
dc.contributor.authorChan, H-K
dc.date.accessioned2020-08-31T09:32:50Z
dc.date.available2020-08-31T09:32:50Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8281
dc.description.abstractCough is an adverse effect that may hinder the delivery of drugs into the lungs. Chemical or mechanical stimulants activate the transient receptor potential in some airway afferent nerves (C‐fibres or A‐fibres) to trigger cough. Types of inhaler device and drug, dose, excipients and formulation characteristics, including pH, tonicity, aerosol output and particle size may trigger cough by stimulating the cough receptors. Release of inflammatory mediators may increase the sensitivity of the cough receptors to stimulants. The cough‐provoking effect of aerosols is enhanced by bronchoconstriction in diseased airways and reduces drug deposition in the target pulmonary regions. In this article, we review the factors by which inhalation products may cause cough.
dc.language.isoenglanti
dc.publisherWiley
dc.relation.ispartofseriesBritish journal of pharmacology
dc.relation.urihttp://dx.doi.org/10.1111/bph.15197
dc.rightsAll rights reserved
dc.subjectadverse effect
dc.subjectaerosol
dc.subjectcough
dc.subjectinhalation
dc.subjectpharmaceutical products
dc.titleCough as an adverse effect on inhalation pharmaceutical products
dc.description.versionfinal draft
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id72608610en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2020 The British Pharmacological Society
dc.relation.doi10.1111/bph.15197
dc.description.reviewstatuspeerReviewed
dc.format.pagerange4096-4112
dc.relation.issn0007-1188
dc.relation.issue18
dc.relation.volume177
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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