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dc.contributor.authorSalomaa, S
dc.contributor.authorBouffler, SD
dc.contributor.authorAtkinson, MJ
dc.contributor.authorCardis, E
dc.contributor.authorHamada, N
dc.date.accessioned2020-09-21T11:32:15Z
dc.date.available2020-09-21T11:32:15Z
dc.date.issued2020
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/8322
dc.description.abstractSince early April 2020, there has been intense debate over proposed clinical use of ionizing radiation to treat life-threatening pneumonia in Coronavirus Disease 2019 (COVID-19) patients. At least twelve relevant papers appeared by 20 May 2020. The radiation dose proposed for clinical trials are a single dose (0.1–1 Gy) or two doses (a few mGy followed by 0.1–0.25 Gy involving a putative adaptive response, or 1–1.5 Gy in two fractions 2–3 days apart). The scientific rationale for such proposed so-called low dose radiotherapy (LDRT) is twofold (note that only doses below 0.1 Gy are considered as low doses in the field of radiation protection, but here we follow the term as conventionally used in the field of radiation oncology). Firstly, the potentially positive observations in human case series and biological studies in rodent models on viral or bacterial pneumonia that were conducted in the pre-antibiotic era. Secondly, the potential anti-inflammatory properties of LDRT, which have been seen when LDRT is applied locally to subacute degenerative joint diseases, mainly in Germany. However, the human and animal studies cited as supportive evidence have significant limitations, and whether LDRT produces anti-inflammatory effects in the inflamed lung or exacerbates ongoing COVID-19 damage remains unclear. Therefore, we conclude that the available scientific evidence does not justify clinical trials of LDRT for COVID-19 pneumonia, with unknown benefit and known mortality risks from radiogenic cancer and circulatory disease. Despite the significant uncertainties in these proposals, some clinical trials are ongoing and planned. This paper gives an overview of current situations surrounding LDRT for COVID-19 pneumonia.
dc.language.isoenglanti
dc.publisherInforma UK Limited
dc.relation.ispartofseriesInternational journal of radiation biology
dc.relation.urihttp://dx.doi.org/10.1080/09553002.2020.1786609
dc.rightsAll rights reserved
dc.subjectCOVID-19
dc.subjectpneumonia
dc.subjectlow dose radiotherapy
dc.subjectclinical trials
dc.subjectadaptive response
dc.titleIs there any supportive evidence for low dose radiotherapy for COVID-19 pneumonia?
dc.description.versionfinal draft
dc.contributor.departmentYmpäristö- ja biotieteiden laitos / Toiminta
uef.solecris.id71591032en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2020 Taylor & Francis Group LLC.
dc.relation.doi10.1080/09553002.2020.1786609
dc.description.reviewstatuspeerReviewed
dc.relation.issn0955-3002
dc.relation.volume[Published online: 13 Jul 20]
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessEi


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